Anti-CDKN3抗体(ab175393)
Key features and details
- Rabbit polyclonal to CDKN3
- Suitable for: IHC-P, ICC/IF, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
概述
-
产品名称
Anti-CDKN3抗体 -
描述
兔多克隆抗体to CDKN3 -
宿主
Rabbit -
经测试应用
适用于: IHC-P, ICC/IF, WBmore details -
种属反应性
与反应: Mouse, Rat, Human
预测可用于: Pig -
免疫原
Recombinant full length protein corresponding to Human CDKN3.
Sequence:MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPG CKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCG IITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLV AACLLLYLSDTISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHL SSRDSQSRSVSR
Database link: Q16667 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading...
-
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
-
Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab175393于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
Use at an assay dependent concentration.
|
|
ICC/IF |
Use at an assay dependent concentration.
|
|
WB |
1/500 - 1/2000. Predicted molecular weight: 24 kDa.
|
说明 |
---|
IHC-P
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
WB
1/500 - 1/2000. Predicted molecular weight: 24 kDa. |
靶标
-
功能
May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. -
疾病相关
Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC) [MIM:114550]. -
序列相似性
Belongs to the protein-tyrosine phosphatase family. -
细胞定位
Cytoplasm > perinuclear region. - Information by UniProt
-
数据库链接
- Entrez Gene: 1033 Human
- Entrez Gene: 72391 Mouse
- Entrez Gene: 397589 Pig
- Entrez Gene: 289993 Rat
- Omim: 123832 Human
- SwissProt: Q16667 Human
- SwissProt: Q810P3 Mouse
- SwissProt: Q9MYN5 Pig
see all -
别名
- CDI1 antibody
- Cdk associated protein phosphatase antibody
- CDK2 associated dual specificity phosphatase antibody
see all
图片
实验方案
数据表及文件
-
SDS download
-
Datasheet download
文献 (2)
ab175393 被引用在 2 文献中.
- Yu H et al. CDKN3 promotes cell proliferation, invasion and migration by activating the AKT signaling pathway in esophageal squamous cell carcinoma. Oncol Lett 19:542-548 (2020). PubMed: 31897169
- Moses RL et al. Novel epoxy-tiglianes stimulate skin keratinocyte wound healing responses and re-epithelialization via protein kinase C activation. Biochem Pharmacol 178:114048 (2020). PubMed: 32446889