Anti-CDK2抗体[AN4.3] (ab6433)
![Western blot - Anti-CDK2 antibody [AN4.3] (ab6433)](https://www.abcam.cn/ps/products/6/ab6433/Images/ab6433_1.jpg "Western blot - Anti-CDK2 antibody [AN4.3] (ab6433)")
Key features and details
- Mouse monoclonal [AN4.3] to CDK2
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG2a
概述
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产品名称
Anti-CDK2抗体[AN4.3]
参阅全部 CDK2 一抗 -
描述
小鼠单克隆抗体[AN4.3] to CDK2 -
宿主
Mouse -
特异性
Reacts with human, mouse and xenopus cdk2. Does not recognise other cdks. -
经测试应用
适用于: WBmore details
不适用于: IP -
种属反应性
与反应: Mouse, Human -
免疫原
Other Immunogen Type corresponding to CDK2.
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表位
The epitope is at the C-terminus. -
阳性对照
- HeLa nuclear extract.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
AN4.3 -
骨髓瘤
Sp2/0-Ag14 -
同种型
IgG2a -
轻链类型
unknown -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 5 µg/ml. Detects a band of approximately 33 kDa (predicted molecular weight: 34 kDa).
|
| 说明 |
|---|
|
WB
Use a concentration of 5 µg/ml. Detects a band of approximately 33 kDa (predicted molecular weight: 34 kDa). |
靶标
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功能
Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2. -
序列相似性
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain. - Information by UniProt
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数据库链接
- Entrez Gene: 1017 Human
- Entrez Gene: 12566 Mouse
- Omim: 116953 Human
- SwissProt: P24941 Human
- SwissProt: P97377 Mouse
- Unigene: 19192 Human
- Unigene: 689624 Human
- Unigene: 111326 Mouse
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别名
- Cdc2 related protein kinase antibody
- cdc2-related protein kinase antibody
- CDC28 antibody
see all
图片
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Western blot - Anti-CDK2 antibody [AN4.3] (ab6433)This image is courtesy of Julian Gannon, CRUK.
Western blot using ab6433 at 5
µ g/ml.Lane 1: HeLa
Lane 2: 293
Lane 3: mouse myeloid cells.
Western blot using ab6433 at 5
µg/ml. Lane 1: HeLa
Lane 2: 293
Lane 3: mouse myeloid cells.
数据表及文件
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SDS download
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Datasheet download
文献 (12)
ab6433 被引用在 12 文献中.
- Wu D et al. The Effects of the CXCR4 Antagonist, AMD3465, on Human Retinal Vascular Endothelial Cells (hRVECs) in a High Glucose Model of Diabetic Retinopathy. Med Sci Monit 25:6946-6954 (2019). PubMed: 31860633
- Li Y et al. Dgat2 reduces hepatocellular carcinoma malignancy via downregulation of cell cycle-related gene expression. Biomed Pharmacother 115:108950 (2019). PubMed: 31078041
- Fan H et al. Long Non-Coding RNAs (lncRNAs) Tumor-Suppressive Role of lncRNA on Chromosome 8p12 (TSLNC8) Inhibits Tumor Metastasis and Promotes Apoptosis by Regulating Interleukin 6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Hypoxia-Inducible Factor 1-alpha (HIF-1a) Signaling Pathway in Non-Small Cell Lung Cancer. Med Sci Monit 25:7624-7633 (2019). PubMed: 31601776
- Yang S et al. microRNA-3129 promotes cell proliferation in gastric cancer cell line SGC7901 via positive regulation of pRb. Braz J Med Biol Res 51:e6452 (2018). PubMed: 29791595
- Parida PK et al. Inhibition of cancer progression by a novel trans-stilbene derivative through disruption of microtubule dynamics, driving G2/M arrest, and p53-dependent apoptosis. Cell Death Dis 9:448 (2018). PubMed: 29670107