Anti-CDK2抗体[AN4.3] (ab6433)
![Western blot - Anti-CDK2 antibody [AN4.3] (ab6433)](https://www.abcam.cn/ps/products/6/ab6433/Images/ab6433_1.jpg "Western blot - Anti-CDK2 antibody [AN4.3] (ab6433)")
Key features and details
- Mouse monoclonal [AN4.3] to CDK2
- Suitable for: WB
- Reacts with: Mouse, Human, Xenopus laevis
- Isotype: IgG2a
概述
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产品名称
Anti-CDK2抗体[AN4.3]
参阅全部 CDK2 一抗 -
描述
小鼠单克隆抗体[AN4.3] to CDK2 -
宿主
Mouse -
特异性
Reacts with human, mouse and xenopus cdk2. Does not recognise other cdks. -
经测试应用
适用于: WBmore details
不适用于: IP -
种属反应性
与反应: Mouse, Human, Xenopus laevis -
免疫原
Other Immunogen Type corresponding to CDK2.
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表位
The epitope is at the C-terminus. -
阳性对照
- HeLa nuclear extract.
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常规说明
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
AN4.3 -
骨髓瘤
Sp2/0-Ag14 -
同种型
IgG2a -
轻链类型
unknown -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
Our Abpromise guarantee covers the use of ab6433 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | Use a concentration of 5 µg/ml. Detects a band of approximately 33 kDa (predicted molecular weight: 34 kDa). |
靶标
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功能
Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2. -
序列相似性
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain. - Information by UniProt
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数据库链接
- Entrez Gene: 1017 Human
- Entrez Gene: 12566 Mouse
- Entrez Gene: 399314 Xenopus laevis
- Omim: 116953 Human
- SwissProt: P24941 Human
- SwissProt: P97377 Mouse
- SwissProt: P23437 Xenopus laevis
- Unigene: 19192 Human
see all -
别名
- Cdc2 related protein kinase antibody
- cdc2-related protein kinase antibody
- CDC28 antibody
see all
图片
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Western blot - Anti-CDK2 antibody [AN4.3] (ab6433)This image is courtesy of Julian Gannon, CRUK.
Western blot using ab6433 at 5
µ g/ml.Lane 1: HeLa
Lane 2: 293
Lane 3: mouse myeloid cells.
Western blot using ab6433 at 5
µg/ml. Lane 1: HeLa
Lane 2: 293
Lane 3: mouse myeloid cells.
数据表及文件
文献 (11)
ab6433 被引用在 11 文献中.
- Wu D et al. The Effects of the CXCR4 Antagonist, AMD3465, on Human Retinal Vascular Endothelial Cells (hRVECs) in a High Glucose Model of Diabetic Retinopathy. Med Sci Monit 25:6946-6954 (2019). PubMed: 31860633
- Li Y et al. Dgat2 reduces hepatocellular carcinoma malignancy via downregulation of cell cycle-related gene expression. Biomed Pharmacother 115:108950 (2019). PubMed: 31078041
- Yang S et al. microRNA-3129 promotes cell proliferation in gastric cancer cell line SGC7901 via positive regulation of pRb. Braz J Med Biol Res 51:e6452 (2018). PubMed: 29791595
- Parida PK et al. Inhibition of cancer progression by a novel trans-stilbene derivative through disruption of microtubule dynamics, driving G2/M arrest, and p53-dependent apoptosis. Cell Death Dis 9:448 (2018). PubMed: 29670107
- Chen P et al. Artesunate Decreases ß-Catenin Expression, Cell Proliferation and Apoptosis Resistance in the MG-63 Human Osteosarcoma Cell Line. Cell Physiol Biochem 43:1939-1949 (2017). PubMed: 29055954
