Anti-CDK1抗体[Y100.4] (ab5467)
Key features and details
- Mouse monoclonal [Y100.4] to CDK1
- Suitable for: WB
- Reacts with: Schizosaccharomyces pombe
- Isotype: IgG2b
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-CDK1抗体[Y100.4]
参阅全部 CDK1 一抗 -
描述
小鼠单克隆抗体[Y100.4] to CDK1 -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Schizosaccharomyces pombe -
免疫原
Synthetic C-terminal peptide:
AKRALQQNYLRDFH
(Schizosaccharomyces pombe) -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Constituent: PBS -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
Y100.4 -
骨髓瘤
Sp2 -
同种型
IgG2b -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
WB
Use at an assay dependent concentration. |
靶标
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功能
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. -
组织特异性
Isoform 2 is found in breast cancer tissues. -
序列相似性
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- SwissProt: P04551 Schizosaccharomyces pombe
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形式
CDK1 can be located to the Nucleus, cytoplasm and Mithocondria. It's cytoplasmic during interphase and reversibly translocated from cytoplasm to the nucleus when phosphorilated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage. -
别名
- Cdc 2 antibody
- Cdc2 antibody
- CDC28A antibody
see all
数据表及文件
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Datasheet download
文献 (21)
ab5467 被引用在 21 文献中.
- Andric V et al. A scaffold lncRNA shapes the mitosis to meiosis switch. Nat Commun 12:770 (2021). PubMed: 33536434
- Mennie AK et al. LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast. Nat Commun 9:586 (2018). WB ; Schizosaccharomyces pombe . PubMed: 29422503
- Fletcher J et al. Nutrient Limitation Inactivates Mrc1-to-Cds1 Checkpoint Signalling in Schizosaccharomyces pombe. Cells 7:N/A (2018). PubMed: 29473861
- Caspari T et al. The drinking water contaminant dibromoacetonitrile delays G1-S transition and suppresses Chk1 activation at broken replication forks. Sci Rep 7:12730 (2017). PubMed: 28986587
- Chan KY et al. Dialogue between centrosomal entrance and exit scaffold pathways regulates mitotic commitment. J Cell Biol 216:2795-2812 (2017). PubMed: 28774892
