Anti-CDK1抗体[Y100.4] (ab5467)
Key features and details
- Mouse monoclonal [Y100.4] to CDK1
- Suitable for: WB
- Reacts with: Schizosaccharomyces pombe
- Isotype: IgG2b
概述
-
产品名称
Anti-CDK1抗体[Y100.4]
参阅全部 CDK1 一抗 -
描述
小鼠单克隆抗体[Y100.4] to CDK1 -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Schizosaccharomyces pombe -
免疫原
Synthetic C-terminal peptide:
AKRALQQNYLRDFH
(Schizosaccharomyces pombe)
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Constituent: PBS -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
Y100.4 -
骨髓瘤
Sp2 -
同种型
IgG2b -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
Our Abpromise guarantee covers the use of ab5467 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | Use at an assay dependent dilution. Detects a band of approximately 34 kDa (predicted molecular weight: 34 kDa). |
靶标
-
功能
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. -
组织特异性
Isoform 2 is found in breast cancer tissues. -
序列相似性
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain. -
细胞定位
Nucleus. - Information by UniProt
-
数据库链接
- SwissProt: P04551 Schizosaccharomyces pombe
-
形式
CDK1 can be located to the Nucleus, cytoplasm and Mithocondria. It's cytoplasmic during interphase and reversibly translocated from cytoplasm to the nucleus when phosphorilated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage. -
别名
- Cdc 2 antibody
- Cdc2 antibody
- CDC28A antibody
see all
数据表及文件
文献 (19)
ab5467 被引用在 19 文献中.
- Mennie AK et al. LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast. Nat Commun 9:586 (2018). WB ; Schizosaccharomyces pombe . PubMed: 29422503
- Fletcher J et al. Nutrient Limitation Inactivates Mrc1-to-Cds1 Checkpoint Signalling in Schizosaccharomyces pombe. Cells 7:N/A (2018). PubMed: 29473861
- Caspari T et al. The drinking water contaminant dibromoacetonitrile delays G1-S transition and suppresses Chk1 activation at broken replication forks. Sci Rep 7:12730 (2017). PubMed: 28986587
- Chan KY et al. Dialogue between centrosomal entrance and exit scaffold pathways regulates mitotic commitment. J Cell Biol 216:2795-2812 (2017). PubMed: 28774892
- Simonetti F et al. Ubiquitination-dependent control of sexual differentiation in fission yeast. Elife 6:N/A (2017). PubMed: 28841135
