概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 序列
      KKKVSRSGLYRSPSMPENLNRPR
    • 氨基酸
      205 to 225

技术指标

Our Abpromise guarantee covers the use of ab204854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    HPLC

    Functional Studies

  • 形式
    Lyophilised
  • 补充说明

    ab204854 (Cdc25C peptide) can be utilized as a substrate for the following active protein kinases:

     

    ab139629 (Active human BRSK2 full length protein)
    ab60762 (Active human Chk1 full length protein)
    ab69918 (Active human Chk1 full length protein)
    ab119135 (Active human MARK2 full length protein)
    ab60012 (Active human Mark3 full length protein)
    ab105211 (Active human MARK4 full length protein)
    ab179497 (Active human Serine/threonine-protein kinase NIM1 full length protein)
    ab125626 (Active human ARK5 full length protein)
    ab105209 (Active human NUAK2 full length protein)

     

     

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • 复溶
    Dilute peptide in distilled water to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.

常规信息

  • 别名
    • CDC 25
    • Cdc 25C
    • CDC25
    • CDC25C
    • Cell division cycle 25 homolog C
    • Cell division cycle 25C
    • Cell division cycle 25C protein
    • Dual specificity phosphatase Cdc25C
    • M phase inducer phosphatase 3
    • M-phase inducer phosphatase 3
    • Mitosis inducer CDC25
    • MPIP3
    • MPIP3_HUMAN
    • Phosphotyrosine phosphatase
    • PPP1R60
    • protein phosphatase 1, regulatory subunit 60
    see all
  • 功能
    Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDK1 and activate its kinase activity.
  • 序列相似性
    Belongs to the MPI phosphatase family.
    Contains 1 rhodanese domain.
  • 发展阶段
    Expressed predominantly in G2 phase.
  • 翻译后修饰
    Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4.
  • 细胞定位
    Nucleus.
  • Information by UniProt

文献

ab204854 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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