Anti-CD8 alpha抗体[IBL-3/25] (ab3081)
![Flow Cytometry - Anti-CD8 alpha antibody [IBL-3/25] (ab3081)](https://www.abcam.cn/ps/products/3/ab3081/Images/ab3081-469632-anticd8-alpha-antibody-ibl3-25-flow-cytometry.jpg "Flow Cytometry - Anti-CD8 alpha antibody [IBL-3/25] (ab3081)")
Key features and details
- Rat monoclonal [IBL-3/25] to CD8 alpha
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Isotype: IgG1
概述
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产品名称
Anti-CD8 alpha抗体[IBL-3/25]
参阅全部 CD8 alpha 一抗 -
描述
大鼠单克隆抗体[IBL-3/25] to CD8 alpha -
宿主
Rat -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Mouse spleen cells.
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阳性对照
- Flow Cyt: mouse peripheral lymph node
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading... -
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
IBL-3/25 -
骨髓瘤
Sp2/0-Ag14 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
Use a concentration of 5 µg/ml.
|
| 说明 |
|---|
|
Flow Cyt
Use a concentration of 5 µg/ml. |
靶标
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功能
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. -
疾病相关
Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. -
序列相似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻译后修饰
All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 12525 Mouse
- SwissProt: P01731 Mouse
- Unigene: 1858 Mouse
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别名
- alpha polypeptide (p32) antibody
- CD_antigen=CD8a antibody
- CD8 antibody
see all
图片
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Flow Cytometry - Anti-CD8 alpha antibody [IBL-3/25] (ab3081)
Flow cytometry analysis of mouse peripheral lymph node labeling CD8 alpha with ab3081 at 5ug/mL.
PE-conjugated anti-rat IgG
Red line: isotype control labeling with <3% positive events
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab3081 被引用在 4 文献中.
- Draghiciu O et al. Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication. Oncoimmunology 4:e989764 (2015). IHC ; Mouse . PubMed: 25949902
- Gao X et al. Role of donor and host cells in muscle-derived stem cell-mediated bone repair: differentiation vs. paracrine effects. FASEB J 28:3792-809 (2014). PubMed: 24843069
- Kersting S et al. The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium. J Inflamm Res 6:71-81 (2013). IHC-FoFr ; Mouse . PubMed: 23667316
- Kotakadi VS et al. Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis. Carcinogenesis 29:1799-806 (2008). IHC-P ; Mouse . PubMed: 18567620