Key features and details
- Mouse monoclonal [CB3-1] to CD79b
- Suitable for: WB, IP, Flow Cyt
- Reacts with: Human
- Isotype: IgG1
存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Preservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
纯度Protein A purified
纯化说明Purified from cell culture supernatant by protein-A affinity chromatography. Purity: > 95% (by SDS-PAGE).
Our Abpromise guarantee covers the use of ab130422 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 26 kDa.|
|IP||Use at an assay dependent concentration.|
|Flow Cyt||Use at an assay dependent concentration.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
功能Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
疾病相关Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
序列相似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 1 ITAM domain.
翻译后修饰Phosphorylated on tyrosine upon B-cell activation.
细胞定位Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
- Information by UniProt
- AGM6 antibody
- B cell antigen receptor complex associated protein beta chain antibody
- B cell specific glycoprotein B29 antibody
ab130422 被引用在 2 文献中.
- Matutes E New additions to antibody panels in the characterisation of chronic lymphoproliferative disorders. J Clin Pathol 55:180-3 (2002). PubMed: 11896067
- Nakamura T et al. Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies. Proc Natl Acad Sci U S A 89:8522-6 (1992). PubMed: 1382292