- 数据表
- 具体的参考文献 (4)
- 实验方案
概述
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产品名称Anti-CD68抗体[PG-M1]
参阅全部 CD68 一抗 -
描述小鼠单克隆抗体[PG-M1] to CD68
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宿主Mouse
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经测试应用适用于: IHC-Pmore details
不适用于: ICC or IHC-Fr -
种属反应性与反应: Human
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免疫原
Gaucher cells
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阳性对照
- IHC-P: Human tonsil and granulomatous inflammatory tissues.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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存储溶液Preservative: 0.05% Sodium azide
Constituents: Tissue culture supernatant, 1% BSA -
纯度Tissue culture supernatant
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克隆单克隆
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克隆编号PG-M1
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同种型IgG3
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轻链类型kappa
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研究领域
相关产品
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Alternative Versions
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Compatible Secondaries
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Recombinant Protein
应用
Our Abpromise guarantee covers the use of ab783 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P | 1/10 - 1/40. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. (use ABC method). We suggest an incubation period of 30-60 minutes at room temperature. |
应用说明
Is unsuitable for ICC or IHC-Fr.
靶标
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功能Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
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组织特异性Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
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序列相似性Belongs to the LAMP family.
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翻译后修饰N- and O-glycosylated.
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细胞定位Cell membrane and Endosome membrane. Lysosome membrane.
- Information by UniProt
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数据库链接
- Entrez Gene: 968 Human
- Omim: 153634 Human
- SwissProt: P34810 Human
- Unigene: 647419 Human
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别名
- CD 68 antibody
- CD68 antibody
- CD68 antigen antibody
see all
图片
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (ab783)](https://www.abcam.cn/ps/products/0/ab783/Images/ab783-289954-CD68PGM1.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (ab783)ab783 staining CD68 in Human tonsil tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (ab783)](https://www.abcam.cn/ps/products/0/ab783/Images/ab783-291423-ab78311485.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (ab783)This image is courtesy of an anonymous Abreview.Paraformaldehyde-fixed, paraffin-embedded human granulomatous inflammatory tissue stained for CD68 using ab783 in immunohistochemical analysis.
文献
This product has been referenced in:
- Hultman K et al. The APOE ?4/?4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients. J Cereb Blood Flow Metab 33:1251-8 (2013). Read more (PubMed: 23652625) »
- Horny HP et al. Immunoreactivity of normal and neoplastic human tissue mast cells with macrophage-associated antibodies, with special reference to the recently developed monoclonal antibody PG-M1. Hum Pathol 24:355-8 (1993). Read more (PubMed: 8491475) »
客户评价及客户问答
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