Anti-CD62E抗体[1.2B6] (ab6630)
Key features and details
- Mouse monoclonal [1.2B6] to CD62E
- Suitable for: Flow Cyt
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-CD62E抗体[1.2B6]
参阅全部 CD62E 一抗 -
描述
小鼠单克隆抗体[1.2B6] to CD62E -
宿主
Mouse -
特异性
This antibody recognises the human CD62E and CD62P cell surface antigens binding to a common epitope on these members of the selectin family. -
经测试应用
适用于: Flow Cytmore details
不适用于: IHC-P -
种属反应性
与反应: Human -
免疫原
Full length protein corresponding to Human CD62E.
Database link: P16581 -
常规说明
This antibody inhibits neutrophil adhesion to E-selectin and to P-selectin. E-selectin (ELAM-1) is expressed on the surface of activated endothelial cells.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
纯化说明
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant. -
Primary antibody说明
This antibody inhibits neutrophil adhesion to E-selectin and to P-selectin. E-selectin (ELAM-1) is expressed on the surface of activated endothelial cells. -
克隆
单克隆 -
克隆编号
1.2B6 -
骨髓瘤
NS1 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
应用 | Ab评论 | 说明 |
---|---|---|
Flow Cyt |
Use a concentration of 10 µg/ml.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
说明 |
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Flow Cyt
Use a concentration of 10 µg/ml. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. -
序列相似性
Belongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 6 Sushi (CCP/SCR) domains. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 6401 Human
- Omim: 131210 Human
- SwissProt: P16581 Human
- Unigene: 82848 Human
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别名
- CD26E antibody
- CD62 antigen-like family member E antibody
- CD62E antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (11)
ab6630 被引用在 11 文献中.
- Yuan X et al. Recipient treatment with acetylcholinesterase inhibitor donepezil attenuates primary graft failure in rats through inhibiting post-transplantational donor heart ischaemia/reperfusion injury. Eur J Cardiothorac Surg 53:400-408 (2018). PubMed: 28950359
- Zhang X et al. Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke. J Neurosci 37:1797-1806 (2017). PubMed: 28093478
- Zhang XJ et al. shRNAs targeting high-mobility group box-1 inhibit E-selectin expression via homeobox A9 in human umbilical vein endothelial cells. Mol Med Rep 7:1251-6 (2013). PubMed: 23403989
- Allen CL et al. Augmented dried versus cryopreserved amniotic membrane as an ocular surface dressing. PLoS One 8:e78441 (2013). PubMed: 24205233
- Zhou H et al. NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion. J Pharmacol Exp Ther 334:260-8 (2010). WB ; Human . PubMed: 20378716