Key features and details
- Mouse monoclonal [MEM-06] to CD41
- Suitable for: Flow Cyt
- Reacts with: Human
- Isotype: IgG1
参阅全部 CD41 一抗
描述小鼠单克隆抗体[MEM-06] to CD41
特异性This antibody reacts with CD41 antigen.
经测试应用适用于: Flow Cytmore details
Tissue, cells or virus corresponding to Human CD41. Tissue/ cell preparation (Human). (Leucocytes of patient suffering from LGL-type leukaemia).
Database link: P08514
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.097% Sodium azide
Concentration information loading...
纯度Protein A purified
纯化说明Purified from TCS. Purity >95% by SDS-PAGE.
- Anti-CD41 antibody [MEM-06], prediluted (PE) (ab134372)
- Anti-CD41 antibody [MEM-06], prediluted (PerCP) (ab134373)
- Anti-CD41 antibody [MEM-06] (FITC) (ab21851)
- Anti-CD41 antibody [MEM-06] (PE/Cy5®) (ab233450)
- Anti-CD41 antibody [MEM-06] (PE/Cy7®) (ab239313)
- Anti-CD41 antibody [MEM-06] (Alexa Fluor® 700) (ab270670)
- Anti-CD41 antibody [MEM-06] (Biotin) (ab28065)
- Anti-CD41 antibody [MEM-06] (APC) (ab55866)
Our Abpromise guarantee covers the use of ab2211 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Flow Cyt||Use a concentration of 2 µg/ml.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
功能Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
组织特异性Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
疾病相关Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
序列相似性Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
- Information by UniProt
- antigen CD41 antibody
- BDPLT16 antibody
- BDPLT2 antibody
ab2211 被引用在 1 文献中.
- Bhagat G et al. Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J Clin Invest 118:281-93 (2008). Flow Cyt ; Human . PubMed: 18064301