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Cardiovascular Angiogenesis Adhesion / ECM Integrins

Anti-CD41抗体[MEM-06] (ab2211)

  • Datasheet
  • SDS
Submit a review Submit a question References (1)

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Key features and details

  • Mouse monoclonal [MEM-06] to CD41
  • Reacts with: Human
  • Isotype: IgG1

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概述

  • 产品名称

    Anti-CD41抗体[MEM-06]
    参阅全部 CD41 一抗
  • 描述

    小鼠单克隆抗体[MEM-06] to CD41
  • 宿主

    Mouse
  • 特异性

    This antibody reacts with CD41 antigen.
  • 种属反应性

    与反应: Human
  • 免疫原

    Tissue, cells or virus corresponding to Human CD41. Tissue/ cell preparation (Human). (Leucocytes of patient suffering from LGL-type leukaemia).
    Database link: P08514

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液

    pH: 7.40
    Preservative: 0.097% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • 纯度

    Protein A purified
  • 纯化说明

    Purified from TCS. Purity >95% by SDS-PAGE.
  • 克隆

    单克隆
  • 克隆编号

    MEM-06
  • 骨髓瘤

    unknown
  • 同种型

    IgG1
  • 轻链类型

    unknown
  • 研究领域

    • Cardiovascular
    • Angiogenesis
    • Adhesion / ECM
    • Integrins
    • Cardiovascular
    • Blood
    • Platelets
    • Immunology
    • Cell Type Markers
    • CD
    • Platelets
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cell Adhesion
    • Integrins
    • Alpha
    • Stem Cells
    • Hematopoietic Progenitors
    • Hematopoietic Stem Cells
    • Murine Lineage Negative
    • Stem Cells
    • Hematopoietic Progenitors
    • Myeloid
    • Thrombocytic Lineage

相关产品

  • Alternative Versions

    • PE Anti-CD41 antibody [MEM-06], prediluted (ab134372)
    • PerCP Anti-CD41 antibody [MEM-06], prediluted (ab134373)
    • FITC Anti-CD41 antibody [MEM-06] (ab21851)
    • PE/Cy5® Anti-CD41 antibody [MEM-06] (ab233450)
    • PE/Cy7® Anti-CD41 antibody [MEM-06] (ab239313)
    • Alexa Fluor® 700 Anti-CD41 antibody [MEM-06] (ab270670)
    • Biotin Anti-CD41 antibody [MEM-06] (ab28065)
    • APC Anti-CD41 antibody [MEM-06] (ab55866)
  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)

靶标

  • 功能

    Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
  • 组织特异性

    Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
  • 疾病相关

    Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
  • 序列相似性

    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
  • 细胞定位

    Membrane.
  • Target information above from: UniProt accession P08514 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 数据库链接

    • Entrez Gene: 3674 Human
    • Omim: 607759 Human
    • SwissProt: P08514 Human
    • Unigene: 411312 Human
    • 别名

      • antigen CD41 antibody
      • BDPLT16 antibody
      • BDPLT2 antibody
      • CD41 antibody
      • CD41B antibody
      • form 2 antibody
      • GP2B antibody
      • GPalpha IIb antibody
      • GPIIb antibody
      • GT antibody
      • GTA antibody
      • HPA3 antibody
      • Integrin alpha 2b antibody
      • Integrin alpha IIb antibody
      • Integrin alpha-IIb light chain antibody
      • Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) antibody
      • ITA2B_HUMAN antibody
      • Itga2b antibody
      • ITGAB antibody
      • platelet fibrinogen receptor, alpha subunit antibody
      • platelet glycoprotein IIb of IIb/IIIa complex antibody
      • Platelet membrane glycoprotein IIb antibody
      • platelet specific antigen BAK antibody
      • PPP1R93 antibody
      see all

    实验方案

    • Flow cytometry protocols

    Click here to view the general protocols

    数据表及文件

    • SDS download

    • Datasheet download

      Download

    文献 (1)

    发表研究结果有使用 ab2211?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab2211 被引用在 1 文献中.

    • Bhagat G  et al. Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J Clin Invest 118:281-93 (2008). Flow Cyt ; Human . PubMed: 18064301

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