存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
存储溶液Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4
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Our Abpromise guarantee covers the use of ab30443 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||1/250 - 1/500.|
|WB||1/1000 - 1/5000. Predicted molecular weight: 38 kDa.|
|ICC/IF||Use at an assay dependent concentration. See Abreview.|
|IP||Use at an assay dependent concentration. PubMed: 24833013|
功能Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
序列相似性Belongs to the peptidase C1 family.
细胞定位Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- Information by UniProt
- Amyloid precursor protein secretase antibody
- APP secretase antibody
- APPS antibody
This product has been referenced in:
- Han X et al. AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation. Aging Cell 15:416-27 (2016). Read more (PubMed: 26890602) »
- Lohoefer F et al. Quantitative expression and localization of cysteine and aspartic proteases in human abdominal aortic aneurysms. Exp Mol Med 46:e95 (2014). WB, IP ; Human . Read more (PubMed: 24833013) »