Anti-NLRC4抗体(ab115537)
Key features and details
- Rabbit polyclonal to NLRC4
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-NLRC4抗体
参阅全部 NLRC4 一抗 -
描述
兔多克隆抗体to NLRC4 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human NLRC4 (C terminal) conjugated to keyhole limpet haemocyanin.
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阳性对照
- Human Brain, Cortex tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -80°C. -
存储溶液
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab115537于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Plays a role in the promotion of apoptosis. -
组织特异性
Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain. -
序列相似性
Contains 1 CARD domain.
Contains 14 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. -
细胞定位
Cytoplasm. Cytoplasmic filaments. - Information by UniProt
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数据库链接
- Entrez Gene: 58484 Human
- Omim: 606831 Human
- SwissProt: Q9NPP4 Human
- Unigene: 574741 Human
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别名
- and NACHT-containing protein antibody
- CARD 12 antibody
- CARD antibody
see all
图片
数据表及文件
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Datasheet download
文献 (3)
ab115537 被引用在 3 文献中.
- Wang L et al. A Novel Mutation in the NBD Domain of NLRC4 Causes Mild Autoinflammation With Recurrent Urticaria. Front Immunol 12:674808 (2021). PubMed: 34248956
- Nakamura H et al. Altered expression of inflammasomes in Hirschsprung's disease. Pediatr Surg Int 35:15-20 (2019). PubMed: 30386901
- Furman D et al. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med 23:174-184 (2017). PubMed: 28092664