Anti-CaMKII alpha抗体(ab131468)
Key features and details
- Rabbit polyclonal to CaMKII alpha
- Suitable for: WB, ICC/IF
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-CaMKII alpha抗体
参阅全部 CaMKII alpha 一抗 -
描述
兔多克隆抗体to CaMKII alpha -
宿主
Rabbit -
特异性
This antibody does cross-react with CAMKII beta protein -
经测试应用
适用于: WB, ICC/IFmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide corresponding to Human CaMKII alpha.
Sequence:Q-E-T-V-D
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阳性对照
- Human hippocampal region tissue; extracts from mouse brain tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
PBS without Mg2+ and Ca2+. -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab131468 was purified by affinity-chromatography using epitope-specific peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab131468于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Detects a band of approximately 50 kDa (predicted molecular weight: 54 kDa).
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ICC/IF |
1/100 - 1/200.
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说明 |
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WB
1/500 - 1/1000. Detects a band of approximately 50 kDa (predicted molecular weight: 54 kDa). |
ICC/IF
1/100 - 1/200. |
靶标
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功能
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. -
序列相似性
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain. -
细胞定位
Cell junction > synapse > presynaptic cell membrane. Cell junction > synapse. Postsynaptic lipid rafts. - Information by UniProt
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数据库链接
- Entrez Gene: 815 Human
- Entrez Gene: 12322 Mouse
- Omim: 114078 Human
- SwissProt: Q9UQM7 Human
- SwissProt: P11798 Mouse
- Unigene: 725992 Human
- Unigene: 131530 Mouse
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别名
- Alpha CaMKII antibody
- Calcium calmodulin dependent protein kinase II antibody
- Calcium/calmodulin dependent protein kinase II alpha B subunit antibody
see all
图片
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All lanes : Anti-CaMKII alpha antibody (ab131468) at 1/500 dilution
Lane 1 : Extracts from mouse brain tissue
Lane 2 : Extracts from mouse brain tissue with blocking peptide
Predicted band size: 54 kDa -
Immunofluorescent analysis of paraffin-embedded Human hippocampal region tissue from the falling sickness disease labelling CaMKII alpha with ab131468 at 1/100 dilution.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab131468 被引用在 5 文献中.
- Munoz-Ballester C et al. Mild Traumatic Brain Injury-Induced Disruption of the Blood-Brain Barrier Triggers an Atypical Neuronal Response. Front Cell Neurosci 16:821885 (2022). PubMed: 35250487
- Shen F et al. Rbfox-1 contributes to CaMKIIα expression and intracerebral hemorrhage-induced secondary brain injury via blocking micro-RNA-124. J Cereb Blood Flow Metab 41:530-545 (2021). PubMed: 32248729
- Alexander GM et al. CA2 neuronal activity controls hippocampal low gamma and ripple oscillations. Elife 7:N/A (2018). PubMed: 30387713
- Lu Y et al. Intracellular Ca2+ homeostasis and JAK1/STAT3 pathway are involved in the protective effect of propofol on BV2 microglia against hypoxia-induced inflammation and apoptosis. PLoS One 12:e0178098 (2017). WB . PubMed: 28542400
- Shinsuke K et al. Chronic irradiation with low-dose-rate 137Cs-? rays inhibits NGF-induced neurite extension of PC12 cells via Ca2+/calmodulin-dependent kinase II activation. J Radiat Res 58:809-815 (2017). PubMed: 29106600