Anti-CACNA1H抗体(ab128251)
Key features and details
- Rabbit polyclonal to CACNA1H
- Suitable for: ELISA, ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CACNA1H抗体
参阅全部 CACNA1H 一抗 -
描述
兔多克隆抗体to CACNA1H -
宿主
Rabbit -
经测试应用
适用于: ELISA, ICC/IF, WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide corresponding to the N terminal domain of Human CACNA1H. (Uniprot: O95180)
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. -
存储溶液
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab128251于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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ICC/IF |
Use at an assay dependent concentration.
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WB | (1) |
Use at an assay dependent concentration.
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说明 |
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ELISA
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
靶标
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功能
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. -
组织特异性
Expressed in kidney, liver, heart, brain. Isoform 2 seems to be testis-specific. -
疾病相关
Defects in CACNA1H are a cause of susceptibility to idiopathic generalized epilepsy type 6 (IGE6) [MIM:611942]. IGE is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. IGE6 is a polygenic and multifactorial disease. -
序列相似性
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1H subfamily. -
结构域
Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. -
翻译后修饰
In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 8912 Human
- Entrez Gene: 58226 Mouse
- Entrez Gene: 114862 Rat
- Omim: 607904 Human
- SwissProt: O95180 Human
- SwissProt: O88427 Mouse
- SwissProt: Q9EQ60 Rat
- Unigene: 459642 Human
see all -
别名
- Alpha1 3.2 antibody
- Alpha13.2 antibody
- CAC1H_HUMAN antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab128251 被引用在 3 文献中.
- Teles E Silva AL et al. Rare CACNA1H and RELN variants interact through mTORC1 pathway in oligogenic autism spectrum disorder. Transl Psychiatry 12:234 (2022). PubMed: 35668055
- Zhang T et al. Propofol Mediated Protection of the Brain From Ischemia/Reperfusion Injury Through the Regulation of Microglial Connexin 43. Front Cell Dev Biol 9:637233 (2021). PubMed: 34169070
- Chen J et al. Roles and mechanisms of TRPC3 and the PLC?/PKC/CPI-17 signaling pathway in regulating parturition. Mol Med Rep 17:898-910 (2018). PubMed: 29115500