Key features and details
- Rabbit polyclonal to C4c+C4b (FITC)
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
描述兔多克隆抗体to C4c+C4b (FITC)
偶联物FITC. Ex: 493nm, Em: 528nm
特异性This antibody reacts with human C4, C4b and C4c but does not react with the C4d epitope.
C4c complement isolated from complement activated human serum.
Fluorescein isothiocyanate (FITC) isomer 1.
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存放说明Shipped at 4°C. Store at +4°C.
存储溶液Preservative: 0.05% Sodium azide
Constituents: PBS, 1% BSA
Concentration information loading...
纯化说明Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins.
相关性C4 plays a central role in the activation of the classical pathway of the complement system. Human complement component C4 is polymorphic at two loci, C4A and C4B. The C4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch) blood group antigens. C4 (either allele A or B) protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.
- Acidic complement C4 antibody
- Basic complement C4 antibody
- CH antibody
ab4216 被引用在 1 文献中.
- Ispasanie E et al. Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations. Virulence 9:1138-1149 (2018). PubMed: 30067453