Anti-C3a R抗体(ab126250)
Key features and details
- Rabbit polyclonal to C3a R
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-C3a R抗体
参阅全部 C3a R 一抗 -
描述
兔多克隆抗体to C3a R -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Chimpanzee, Non human primates, Macaque monkey, Orangutan -
免疫原
Recombinant fragment corresponding to Human C3a R aa 1-209.
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阳性对照
- A549 whole cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab126250于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 54 kDa. Optimal working dilutions should be determined experimentally by the user
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IHC-P |
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 54 kDa. Optimal working dilutions should be determined experimentally by the user |
IHC-P
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. -
组织特异性
Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
翻译后修饰
Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 719 Human
- Entrez Gene: 100171704 Orangutan
- Omim: 605246 Human
- SwissProt: Q16581 Human
- SwissProt: Q5REI5 Orangutan
- Unigene: 591148 Human
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别名
- AZ 3B antibody
- AZ3B antibody
- C3a anaphylatoxin chemotactic receptor antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab126250 被引用在 6 文献中.
- Luo S et al. The complement C3a-C3aR and C5a-C5aR pathways promote viability and inflammation of human retinal pigment epithelium cells by targeting NF-κB signaling. Exp Ther Med 24:493 (2022). PubMed: 35837068
- Zou T et al. C3AR1 mRNA as a Potential Therapeutic Target Associates With Clinical Outcomes and Tumor Microenvironment in Osteosarcoma. Front Med (Lausanne) 8:642615 (2021). PubMed: 33748161
- Garcia-Arguinzonis M et al. Alternative C3 Complement System: Lipids and Atherosclerosis. Int J Mol Sci 22:N/A (2021). PubMed: 34066088
- Wu H et al. Circular RNA circUBAP2 regulates proliferation and invasion of osteosarcoma cells through miR-641/YAP1 axis. Cancer Cell Int 20:223 (2020). PubMed: 32528231
- Huang X et al. Neuronal complement cascade drives bone cancer pain via C3R mediated microglial activation. Brain Res 1698:81-88 (2018). PubMed: 29909203
- Wang X et al. Evaluation of expression levels and mechanism of complement activation. Exp Ther Med 14:2493-2496 (2017). PubMed: 28962185