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ab32072 被引用在 341 文献中.

  • Lewis LM  et al. Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc. Elife 7:N/A (2018). PubMed: 29313490
  • Ikenoue T  et al. Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation. Sci Rep 8:2021 (2018). WB ; Mouse . PubMed: 29386660
  • Zhu L  et al. TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/ß-catenin pathway. J Transl Med 16:7 (2018). PubMed: 29343267
  • Akiyama T  et al. Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing. Sci Rep 8:1189 (2018). PubMed: 29352121
  • Pettersson A  et al. MYC Overexpression at the Protein and mRNA Level and Cancer Outcomes among Men Treated with Radical Prostatectomy for Prostate Cancer. Cancer Epidemiol Biomarkers Prev 27:201-207 (2018). PubMed: 29141848
  • Gonsalves WI  et al. Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies. JCI Insight 3:N/A (2018). PubMed: 29321378
  • Natale CA  et al. Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade. Elife 7:N/A (2018). PubMed: 29336307
  • Groulx JF  et al. MYC Regulates a6 Integrin Subunit Expression and Splicing Under Its Pro-Proliferative ITGA6A Form in Colorectal Cancer Cells. Cancers (Basel) 10:N/A (2018). PubMed: 29401653
  • Murai N  et al. Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 2. Sci Rep 8:3005 (2018). PubMed: 29445227
  • Niemas-Teshiba R  et al. MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children's oncology group. Oncotarget 9:6416-6432 (2018). PubMed: 29464082
  • Huang Y  et al. S6K1 phosphorylation-dependent degradation of Mxi1 by ß-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer. Theranostics 8:1286-1300 (2018). PubMed: 29507620
  • Zhao SJ  et al. SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway. Cell Death Dis 9:390 (2018). PubMed: 29523788
  • Li Z  et al. Novel biomarkerZCCHC13revealed by integrating DNA methylation and mRNA expression data in non-obstructive azoospermia. Cell Death Discov 4:36 (2018). PubMed: 29531833
  • Zhang L  et al. Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression. Nat Commun 9:1047 (2018). PubMed: 29535359
  • Wang W  et al. SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition. J Exp Clin Cancer Res 37:37 (2018). WB ; Human . PubMed: 29475441
  • Colini Baldeschi A  et al. Atrial Natriuretic Peptide Acts as a Neuroprotective Agent in in Vitro Models of Parkinson's Disease via Up-regulation of the Wnt/ß-Catenin Pathway. Front Aging Neurosci 10:20 (2018). WB . PubMed: 29449807
  • Monteverde T  et al. Calcium signalling links MYC to NUAK1. Oncogene 37:982-992 (2018). PubMed: 29106388
  • Ma Y  et al. High expression of PRPS1 induces an anti-apoptotic effect in B-ALL cell lines and predicts an adverse prognosis in Chinese children with B-ALL. Oncol Lett 15:4314-4322 (2018). PubMed: 29541198
  • Jiang Y  et al. MAP30 promotes apoptosis of U251 and U87 cells by suppressing the LGR5 and Wnt/ß-catenin signaling pathway, and enhancing Smac expression. Oncol Lett 15:5833-5840 (2018). PubMed: 29556310
  • Arribas Arranz J  et al. Suitability of Yin Yang 1 transcript and protein levels for biomarker studies in B cell non-Hodgkin lymphoma. Biomark Res 6:11 (2018). PubMed: 29564133
  • Malchenko S  et al. Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors. Oncotarget 9:13733-13747 (2018). PubMed: 29568390
  • Allen J  et al. Co-expression of MYC and BCL2 predicts poorer outcomes for relapsed/refractory diffuse large B-cell lymphoma with R-ICE and intent to transplant. Ther Adv Hematol 9:81-87 (2018). IHC-P ; Human . PubMed: 29623179
  • Qian W  et al. Secretome analysis of rat osteoblasts during icariin treatment induced osteogenesis. Mol Med Rep 17:6515-6525 (2018). PubMed: 29532868
  • Hirth CG  et al. PanCD44 Immunohistochemical Evaluation in Prostatectomies from Patients with Adenocarcinoma. Biomed Res Int 2018:2061268 (2018). PubMed: 29682524
  • Sun M  et al. Targeted delivery of immuno-RNase may improve cancer therapy. Cancer Cell Int 18:58 (2018). PubMed: 29686536
  • Wang F & Sun Y Overexpression of Myosin Phosphatase Target Subunit 1 (MYPT1) Inhibits Tumor Progression and Metastasis of Gastric Cancer. Med Sci Monit 24:2508-2517 (2018). PubMed: 29687789
  • Ji F  et al. Low expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection. BMC Cancer 18:460 (2018). PubMed: 29690860
  • Brandt LP  et al. Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma. Oncotarget 9:19753-19766 (2018). PubMed: 29731980
  • Chen L  et al. Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer. Evid Based Complement Alternat Med 2018:7343090 (2018). PubMed: 29736179
  • Gao H  et al. LncRNA ZEB2-AS1 promotes pancreatic cancer cell growth and invasion through regulating the miR-204/HMGB1 axis. Int J Biol Macromol 116:545-551 (2018). PubMed: 29753015
  • Steger CM  et al. Gene therapy with antisense oligonucleotides silencing c-myc reduces neointima formation and vessel wall thickness in a mouse model of vein graft disease. Exp Mol Pathol 105:1-9 (2018). IHC-P ; Mouse . PubMed: 29775572
  • Duan Z  et al. Importin a5 negatively regulates importin ß1-mediated nuclear import of Newcastle disease virus matrix protein and viral replication and pathogenicity in chicken fibroblasts. Virulence 9:783-803 (2018). PubMed: 29532715
  • Chau KF  et al. Downregulation of ribosome biogenesis during early forebrain development. Elife 7:N/A (2018). PubMed: 29745900
  • Huang PS  et al. The Long Non-Coding RNA MIR503HG Enhances Proliferation of Human ALK-Negative Anaplastic Large-Cell Lymphoma. Int J Mol Sci 19:N/A (2018). PubMed: 29758012
  • Zhang C  et al. The novel 19q13 KRAB zinc-finger tumour suppressor ZNF382 is frequently methylated in oesophageal squamous cell carcinoma and antagonises Wnt/ß-catenin signalling. Cell Death Dis 9:573 (2018). PubMed: 29760376
  • Lei T  et al. Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation. Nat Commun 9:1876 (2018). PubMed: 29760377
  • Wang X  et al. Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway. Cell Death Dis 9:578 (2018). PubMed: 29784961
  • Wang Q  et al. NHERF1 inhibits beta-catenin-mediated proliferation of cervical cancer cells through suppression of alpha-actinin-4 expression. Cell Death Dis 9:668 (2018). PubMed: 29867145
  • Meder L  et al. LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model. Oncogene 37:2746-2756 (2018). PubMed: 29503447
  • Menguy S  et al. Double-hit or dual expression of MYC and BCL2 in primary cutaneous large B-cell lymphomas. Mod Pathol N/A:N/A (2018). PubMed: 29581544
  • Scully KM  et al. E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53. Cell Mol Gastroenterol Hepatol 6:181-198 (2018). PubMed: 30003124
  • Zhao N  et al. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest 128:1283-1299 (2018). PubMed: 29480818
  • Nie X  et al. mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development. PLoS Genet 14:e1007491 (2018). PubMed: 29975682
  • Weltner J  et al. Human pluripotent reprogramming with CRISPR activators. Nat Commun 9:2643 (2018). PubMed: 29980666
  • Cummins CB  et al. Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway. Int J Mol Sci 19:N/A (2018). PubMed: 29795016
  • Teng CF  et al. Liver regeneration accelerates hepatitis B virus-related tumorigenesis of hepatocellular carcinoma. Mol Oncol 12:1175-1187 (2018). PubMed: 29729074
  • Xu X  et al. PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion. J Exp Clin Cancer Res 37:158 (2018). PubMed: 30016974
  • Zou J  et al. MYC inhibition increases PD-L1 expression induced by IFN-? in hepatocellular carcinoma cells. Mol Immunol 101:203-209 (2018). PubMed: 30007230
  • Wang J  et al. Collaborating genomic, transcriptomic and microbiomic alterations lead to canine extreme intestinal polyposis. Oncotarget 9:29162-29179 (2018). PubMed: 30018743
  • Henry KE  et al. Noninvasive 89Zr-Transferrin PET Shows Improved Tumor Targeting Compared with 18F-FDG PET in MYC-Overexpressing Human Triple-Negative Breast Cancer. J Nucl Med 59:51-57 (2018). PubMed: 28848040
  • Xin J  et al. miR-204 functions as a tumor suppressor gene, at least partly by suppressing CYP27A1 in glioblastoma. Oncol Lett 16:1439-1448 (2018). PubMed: 30008822
  • Cai L  et al. Naringin inhibits ovarian tumor growth by promoting apoptosis: An in vivo study. Oncol Lett 16:59-64 (2018). PubMed: 29928387
  • Donnella HJ  et al. Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. Nat Chem Biol 14:768-777 (2018). PubMed: 29942081
  • Yang WH  et al. Heterogeneous nuclear ribonucleoprotein M promotes the progression of breast cancer by regulating the axin/ß-catenin signaling pathway. Biomed Pharmacother 105:848-855 (2018). PubMed: 30021377
  • Xie H  et al. IRE1a RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers. J Clin Invest 128:1300-1316 (2018). PubMed: 29381485
  • Wang X  et al. Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells. Oncol Lett 16:585-593 (2018). PubMed: 29928445
  • Baena-Del Valle JA  et al. MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer. J Pathol 244:11-24 (2018). IHC-P ; Human . PubMed: 28888037
  • Wang J  et al. Targeting c-Myc: JQ1 as a promising option for c-Myc-amplified esophageal squamous cell carcinoma. Cancer Lett 419:64-74 (2018). PubMed: 29366803
  • Wang S  et al. SH2B1 promotes epithelial-mesenchymal transition through the IRS1/ß-catenin signaling axis in lung adenocarcinoma. Mol Carcinog 57:640-652 (2018). WB ; Human . PubMed: 29380446
  • Shannon ML  et al. Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. Am J Pathol 188:1334-1344 (2018). PubMed: 29545198
  • Wang D  et al. MiR-182 promotes prostate cancer progression through activating Wnt/ß-catenin signal pathway. Biomed Pharmacother 99:334-339 (2018). WB . PubMed: 29353209
  • Chan KH  et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem 61:504-513 (2018). PubMed: 28595007
  • Mishra P  et al. ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming. J Clin Invest 128:323-340 (2018). PubMed: 29202474
  • Gallagher SJ  et al. HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma. Int J Cancer 142:1926-1937 (2018). PubMed: 29210065
  • Mo H  et al. ATF4 regulated by MYC has an important function in anoikis resistance in human osteosarcoma cells. Mol Med Rep 17:3658-3666 (2018). PubMed: 29257326
  • Haikala HM  et al. Myc requires RhoA/SRF to reprogram glutamine metabolism. Small GTPases 9:274-282 (2018). PubMed: 27532209
  • Tuzlak S  et al. Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis. FEBS J 285:1403-1418 (2018). PubMed: 29498802
  • Zhang Y  et al. CREPT facilitates colorectal cancer growth through inducing Wnt/ß-catenin pathway by enhancing p300-mediated ß-catenin acetylation. Oncogene 37:3485-3500 (2018). PubMed: 29563608
  • Wang S  et al. Effect of aromatase inhibitor letrozole on the proliferation of spermatogonia by regulating the MAPK pathway. Exp Ther Med 15:5269-5274 (2018). PubMed: 29805545
  • Xiang Z  et al. Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer. Front Pharmacol 9:861 (2018). PubMed: 30123134
  • Wang Y  et al. Long non-coding RNA DSCR8 acts as a molecular sponge for miR-485-5p to activate Wnt/ß-catenin signal pathway in hepatocellular carcinoma. Cell Death Dis 9:851 (2018). PubMed: 30154476
  • Bao Y  et al. Carnosine Inhibits the Proliferation of Human Cervical Gland Carcinoma Cells Through Inhibiting Both Mitochondrial Bioenergetics and Glycolysis Pathways and Retarding Cell Cycle Progression. Integr Cancer Ther 17:80-91 (2018). PubMed: 28008780
  • Sowalsky AG  et al. Gleason Score 7 Prostate Cancers Emerge through Branched Evolution of Clonal Gleason Pattern 3 and 4. Clin Cancer Res 23:3823-3833 (2017). PubMed: 28119368
  • Xie Y & Wang B Downregulation of TNFAIP2 suppresses proliferation and metastasis in esophageal squamous cell carcinoma through activation of the Wnt/ß-catenin signaling pathway. Oncol Rep 37:2920-2928 (2017). PubMed: 28393234
  • Yu P  et al. FGF-dependent metabolic control of vascular development. Nature 545:224-228 (2017). PubMed: 28467822
  • Asghar US  et al. Single-Cell Dynamics Determines Response to CDK4/6 Inhibition in Triple-Negative Breast Cancer. Clin Cancer Res 23:5561-5572 (2017). PubMed: 28606920
  • Zhang C  et al. TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3. Mol Oncol 11:280-294 (2017). PubMed: 28100038
  • Anderton B  et al. MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer. EMBO Rep 18:569-585 (2017). PubMed: 28219903
  • Gadd MS  et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol 13:514-521 (2017). PubMed: 28288108
  • Altman BJ  et al. Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERBa. Nat Commun 8:14862 (2017). PubMed: 28332504
  • Zhang B  et al. Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway. Am J Cancer Res 7:1337-1349 (2017). WB ; Human . PubMed: 28670495
  • Oh JM  et al. U1 snRNP telescripting regulates a size-function-stratified human genome. Nat Struct Mol Biol 24:993-999 (2017). WB ; Human . PubMed: 28967884
  • Ma SD  et al. Latent Membrane Protein 1 (LMP1) and LMP2A Collaborate To Promote Epstein-Barr Virus-Induced B Cell Lymphomas in a Cord Blood-Humanized Mouse Model but Are Not Essential. J Virol 91:N/A (2017). IHC . PubMed: 28077657
  • Flores A  et al. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol 19:1017-1026 (2017). PubMed: 28812580
  • Kalimutho M  et al. Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae. Mol Oncol 11:470-490 (2017). PubMed: 28173629
  • Wang T  et al. Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt/ß-catenin signaling pathway. Oncotarget 8:18991-19012 (2017). PubMed: 28177909
  • Justus CR  et al. Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies. J Transl Med 15:204 (2017). IHC . PubMed: 29017562
  • Effenberger M  et al. Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation. Oncotarget 8:85858-85867 (2017). WB ; Human . PubMed: 29156762
  • Rinaldi L  et al. Mitochondrial AKAP1 supports mTOR pathway and tumor growth. Cell Death Dis 8:e2842 (2017). IHC ; Human . PubMed: 28569781
  • Rohban S  et al. The cohesin complex prevents Myc-induced replication stress. Cell Death Dis 8:e2956 (2017). WB . PubMed: 28749464
  • Tang L  et al. Expression of NUAK2 in gastric cancer tissue and its effects on the proliferation of gastric cancer cells. Exp Ther Med 13:676-680 (2017). PubMed: 28352350
  • Wang JH  et al. Overexpression of MYC and BCL2 Predicts Poor Prognosis in Patients with Extranodal NK/T-cell Lymphoma, Nasal Type. J Cancer 8:793-800 (2017). PubMed: 28382141
  • Singleton KR  et al. Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence. Cell Rep 21:2796-2812 (2017). IHC-P ; Human . PubMed: 29212027
  • Fujii K  et al. MYB, MYBL1, MYBL2 and NFIB gene alterations and MYC overexpression in salivary gland adenoid cystic carcinoma. Histopathology 71:823-834 (2017). PubMed: 28594149
  • Marión RM  et al. Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis. Stem Cell Reports 8:460-475 (2017). PubMed: 28162998
  • Fan J  et al. A novel role of CKIP-1 in promoting megakaryocytic differentiation. Oncotarget 8:30138-30150 (2017). PubMed: 28404913
  • Heo MH  et al. IRF4/MUM1 expression is associated with poor survival outcomes in patients with peripheral T-cell lymphoma. J Cancer 8:1018-1024 (2017). PubMed: 28529614
  • Ishii N  et al. Poor prognosis in cholangiocarcinoma patients with low FBXW7 expression is improved by chemotherapy. Oncol Lett 13:3653-3661 (2017). PubMed: 28521468
  • Xiao J  et al. Efficacy and tolerability of chemotherapy in Chinese patients with AIDS-related Burkitt lymphoma and diffuse large B-cell lymphoma: An observational study. Sci Rep 7:1905 (2017). PubMed: 28507339
  • Tian C  et al. ABCG1 as a potential oncogene in lung cancer. Exp Ther Med 13:3189-3194 (2017). PubMed: 28588672
  • Bolognesi MM  et al. Multiplex Staining by Sequential Immunostaining and Antibody Removal on Routine Tissue Sections. J Histochem Cytochem 65:431-444 (2017). PubMed: 28692376
  • Wang S  et al. Fibulin-3 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition and activating the Wnt/ß-catenin signaling pathway. Sci Rep 7:6215 (2017). PubMed: 28740094
  • Peng Y  et al. Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma. J Cancer 8:1655-1664 (2017). PubMed: 28775785
  • Gupta N  et al. High Myc expression and transcription activity underlies intra-tumoral heterogeneity in triple-negative breast cancer. Oncotarget 8:28101-28115 (2017). IHC ; Human . PubMed: 28427212
  • Wang C  et al. Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/ß-catenin and Wnt/PCP signaling pathways. Oncol Lett 13:3479-3486 (2017). Human . PubMed: 28521453
  • Liu X  et al. MiR-302a sensitizes leukemia cells to etoposide by targeting Rad52. Oncotarget 8:73884-73891 (2017). WB ; Human . PubMed: 29088754
  • Baudin M  et al. Analysis of the ZAR1 Immune Complex Reveals Determinants for Immunity and Molecular Interactions. Plant Physiol 174:2038-2053 (2017). WB, IP ; Nicotiana benthamiana . PubMed: 28652264
  • Jiang XN  et al. Anaplastic lymphoma kinase-positive large B-cell lymphoma: Clinico-pathological study of 17 cases with review of literature. PLoS One 12:e0178416 (2017). IHC-P ; Human . PubMed: 28665943
  • Matkar S  et al. Kinase inhibitors of HER2/AKT pathway induce ERK phosphorylation via a FOXO-dependent feedback loop. Am J Cancer Res 7:1476-1485 (2017). WB ; Human . PubMed: 28744398
  • Yahiaoui A  et al. PI3Kd inhibitor idelalisib in combination with BTK inhibitor ONO/GS-4059 in diffuse large B cell lymphoma with acquired resistance to PI3Kd and BTK inhibitors. PLoS One 12:e0171221 (2017). WB, IHC . PubMed: 28178345
  • Cui L  et al. Inhibition of coiled coil domain containing protein 69 enhances platinum-induced apoptosis in ovarian cancer cells. Oncotarget 8:101634-101648 (2017). PubMed: 29254192
  • Chen BJ  et al. Primary effusion lymphoma in Taiwan shows two distinctive clinicopathological subtypes with rare human immunodeficiency virus association. Histopathology N/A:N/A (2017). PubMed: 29206290
  • Janghorban M  et al. The tumor suppressor phosphatase PP2A-B56a regulates stemness and promotes the initiation of malignancies in a novel murine model. PLoS One 12:e0188910 (2017). PubMed: 29190822
  • Ninomiya T  et al. Iron depletion is a novel therapeutic strategy to target cancer stem cells. Oncotarget 8:98405-98416 (2017). PubMed: 29228699
  • Gnanasundram SV  et al. PI3Kd activates E2F1 synthesis in response to mRNA translation stress. Nat Commun 8:2103 (2017). PubMed: 29235459
  • Chen W  et al. MALAT1-miR-101-SOX9 feedback loop modulates the chemo-resistance of lung cancer cell to DDP via Wnt signaling pathway. Oncotarget 8:94317-94329 (2017). PubMed: 29212230
  • Rao SS  et al. Synergistic effect of eribulin and CDK inhibition for the treatment of triple negative breast cancer. Oncotarget 8:83925-83939 (2017). PubMed: 29137393
  • Schuler F  et al. Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis. Nat Commun 8:1697 (2017). PubMed: 29167438
  • Mogavero A  et al. Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production. Sci Rep 7:15992 (2017). PubMed: 29167573
  • Farrell AS  et al. MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nat Commun 8:1728 (2017). PubMed: 29170413
  • Bellut J  et al. Differential prognostic value of MYC immunohistochemistry in subtypes of papillary renal cell carcinoma. Sci Rep 7:16424 (2017). PubMed: 29180625
  • Muzumdar MD  et al. Survival of pancreatic cancer cells lacking KRAS function. Nat Commun 8:1090 (2017). PubMed: 29061961
  • Gou Q  et al. Profiling and bioinformatic analysis of circular RNA expression regulated by c-Myc. Oncotarget 8:71587-71596 (2017). PubMed: 29069731
  • Mao XW  et al. CUL4B promotes bladder cancer metastasis and induces epithelial-to-mesenchymal transition by activating the Wnt/ß-catenin signaling pathway. Oncotarget 8:77241-77253 (2017). PubMed: 29100384
  • Ryan RJH  et al. A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell Rep 21:784-797 (2017). PubMed: 29045844
  • Lou Y  et al. Linc-ROR induces epithelial-to-mesenchymal transition in ovarian cancer by increasing Wnt/ß-catenin signaling. Oncotarget 8:69983-69994 (2017). PubMed: 29050257
  • Lv C  et al. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nat Commun 8:1036 (2017). PubMed: 29051494
  • Tuo H  et al. MiR-324-3p promotes tumor growth through targeting DACT1 and activation of Wnt/ß-catenin pathway in hepatocellular carcinoma. Oncotarget 8:65687-65698 (2017). PubMed: 29029464
  • Gonçalves AF  et al. Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells. Nat Commun 8:1466 (2017). PubMed: 29133867
  • Chen M  et al. The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. J Cell Biol 216:641-656 (2017). PubMed: 28193700
  • Riemer P  et al. Oncogenic ß-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. J Cell Biol 216:1567-1577 (2017). PubMed: 28442534
  • Yuan Y  et al. miR-24-3p Is Overexpressed in Hodgkin Lymphoma and Protects Hodgkin and Reed-Sternberg Cells from Apoptosis. Am J Pathol 187:1343-1355 (2017). PubMed: 28432871
  • Salati S  et al. Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells. Oncotarget 8:49451-49469 (2017). PubMed: 28533480
  • Bilger A  et al. Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)- induced lymphoproliferative disease and lytic viral replication. Oncotarget 8:44266-44280 (2017). PubMed: 28574826
  • Xiang S  et al. Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/ß-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer. Int J Oncol 51:801-811 (2017). PubMed: 28677721
  • Li J  et al. miRNA-1284 inhibits cell growth and induces apoptosis of lung cancer cells. Mol Med Rep 16:3049-3054 (2017). PubMed: 28713980
  • Hu J  et al. Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. Stem Cell Reports 9:464-477 (2017). PubMed: 28793246
  • Lu W  et al. Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling. Sci Rep 7:8402 (2017). PubMed: 28827748
  • Delás MJ  et al. lncRNA requirements for mouse acute myeloid leukemia and normal differentiation. Elife 6:N/A (2017). PubMed: 28875933
  • Liu B  et al. Transgenic overexpression of NanogP8 in the mouse prostate is insufficient to initiate tumorigenesis but weakly promotes tumor development in the Hi-Myc mouse model. Oncotarget 8:52746-52760 (2017). PubMed: 28881767
  • Trempolec N  et al. Induction of oxidative metabolism by the p38a/MK2 pathway. Sci Rep 7:11367 (2017). PubMed: 28900160
  • Wang F  et al. Morusin inhibits cell proliferation and tumor growth by down-regulating c-Myc in human gastric cancer. Oncotarget 8:57187-57200 (2017). PubMed: 28915664
  • Mu J  et al. Dickkopf-related protein 2 induces G0/G1 arrest and apoptosis through suppressing Wnt/ß-catenin signaling and is frequently methylated in breast cancer. Oncotarget 8:39443-39459 (2017). PubMed: 28467796
  • Nguyen L  et al. The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects. Genes (Basel) 8:N/A (2017). IHC-P . PubMed: 28379189
  • Quesada AE  et al. Increased MYC copy number is an independent prognostic factor in patients with diffuse large B-cell lymphoma. Mod Pathol 30:1688-1697 (2017). IHC-P ; Human . PubMed: 28776574
  • Weng S  et al. Restoration of MYC-repressed targets mediates the negative effects of GM-CSF on RUNX1-ETO leukemogenicity. Leukemia 31:159-169 (2017). WB . PubMed: 27389055
  • Lu T  et al. Adamts18 deficiency promotes colon carcinogenesis by enhancing ß-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer. Oncotarget 8:18979-18990 (2017). WB, IHC ; Mouse . PubMed: 28145888
  • Yuan H  et al. HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6/E7 viral oncogenes. Sci Rep 7:45617 (2017). IHC-P ; Human . PubMed: 28378747
  • Barfeld SJ  et al. c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks. EBioMedicine 18:83-93 (2017). WB, IHC ; Human . PubMed: 28412251
  • Hogg SJ  et al. BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1. Cell Rep 18:2162-2174 (2017). ChIP ; Human . PubMed: 28249162
  • Ma L  et al. Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer. Oncotarget 8:4125-4135 (2017). WB ; Human . PubMed: 27911852
  • Lines KE  et al. Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors. Oncogenesis 6:e332 (2017). WB ; Mouse . PubMed: 28504695
  • Xin B  et al. Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways. Oncogene N/A:N/A (2017). IHC-P ; Mouse . PubMed: 28481866
  • Malchenko S  et al. Stabilization of HIF-1a and HIF-2a, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model. PLoS One 12:e0173106 (2017). IHC-P ; Human . PubMed: 28249000
  • Hall Z  et al. Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer. Cancer Res 76:4608-18 (2016). IHC-P ; Human . PubMed: 27335109
  • Ma L  et al. Fat4 suppression induces Yap translocation accounting for the promoted proliferation and migration of gastric cancer cells. Cancer Biol Ther 17:36-47 (2016). WB ; Human . PubMed: 26575609
  • Wu Y  et al. Low expression of secreted frizzled-related protein 2 and nuclear accumulation of ß-catenin in aggressive nonfunctioning pituitary adenoma. Oncol Lett 12:199-206 (2016). WB ; Human . PubMed: 27347125
  • Li T  et al. Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure. Oncotarget 7:78872-78882 (2016). ICC/IF ; Mouse . PubMed: 27713163
  • Nowacka JD  et al. MEK1 is required for the development of NRAS-driven leukemia. Oncotarget 7:80113-80130 (2016). WB ; Human . PubMed: 27741509
  • Griffin NI  et al. ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC. Breast Cancer Res 18:113 (2016). WB ; Human . PubMed: 27852327
  • Yu Y  et al. Preterm infant gut microbiota affects intestinal epithelial development in a humanized microbiome gnotobiotic mouse model. Am J Physiol Gastrointest Liver Physiol 311:G521-32 (2016). IHC ; Human . PubMed: 27492329
  • Nakazawa MS  et al. Epigenetic re-expression of HIF-2a suppresses soft tissue sarcoma growth. Nat Commun 7:10539 (2016). WB . PubMed: 26837714
  • Hanaford AR  et al. DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets. Clin Cancer Res 22:3903-14 (2016). PubMed: 27012813
  • Oh EJ  et al. Long Non-coding RNA HOTAIR Expression in Diffuse Large B-Cell Lymphoma: In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 Trimethylation. J Pathol Transl Med 50:369-76 (2016). PubMed: 27550047
  • Sun X  et al. MAVS maintains mitochondrial homeostasis via autophagy. Cell Discov 2:16024 (2016). PubMed: 27551434
  • Maeshima AM  et al. Clinicopathological features of histological transformation from extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue to diffuse large B-cell lymphoma: an analysis of 467 patients. Br J Haematol 174:923-31 (2016). PubMed: 27460179
  • Huang YW  et al. Black raspberries demethylate Sfrp4, a WNT pathway antagonist, in rat esophageal squamous cell papilloma. Mol Carcinog 55:1867-1875 (2016). PubMed: 27696538
  • Choe JY  et al. PELI1 expression is correlated with MYC and BCL6 expression and associated with poor prognosis in diffuse large B-cell lymphoma. Mod Pathol 29:1313-1323 (2016). PubMed: 27469333
  • Gao K  et al. Deregulated WWOX is involved in a negative feedback loop with microRNA-214-3p in osteosarcoma. Int J Mol Med N/A:N/A (2016). WB . PubMed: 27840941
  • Courville EL  et al. EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations. Mod Pathol 29:1200-11 (2016). PubMed: 27443517
  • Gupta NK  et al. Long-term survival in AIDS-related primary central nervous system lymphoma. Neuro Oncol N/A:N/A (2016). PubMed: 27576871
  • Manerba M  et al. Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells. Eur J Pharm Sci 96:37-44 (2016). PubMed: 27622920
  • Rui L  et al. Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A 113:E7260-E7267 (2016). PubMed: 27799566
  • Dela Cruz FS  et al. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med 8:116 (2016). WB . PubMed: 27799065
  • Wu C  et al. A positive feedback loop involving the Wnt/ß-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subpopulation in ALK-positive anaplastic large cell lymphoma. J Hematol Oncol 9:120 (2016). IHC, ICC/IF . PubMed: 27821172
  • Zhao X  et al. Inhibition of mTORC1 signaling sensitizes hepatocellular carcinoma cells to glycolytic stress. Am J Cancer Res 6:2289-2298 (2016). WB ; Human . PubMed: 27822418
  • Lorenzin F  et al. Different promoter affinities account for specificity in MYC-dependent gene regulation. Elife 5:N/A (2016). PubMed: 27460974
  • Shi X  et al. Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-ß-dependent mechanisms. Proc Natl Acad Sci U S A 113:E4558-66 (2016). PubMed: 27432991
  • Han A  et al. p63a modulates c-Myc activity via direct interaction and regulation of MM1 protein stability. Oncotarget 7:44277-44287 (2016). WB ; Human . PubMed: 27341130
  • Grampp S  et al. Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer. Nat Commun 7:13183 (2016). WB, IHC-P ; Human . PubMed: 27774982
  • Jin YJ  et al. Epidermal CYLD inactivation sensitizes mice to the development of sebaceous and basaloid skin tumors. JCI Insight 1:N/A (2016). IF, IHC . PubMed: 27478875
  • Lee KS  et al. Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ß-catenin. BMC Cancer 16:730 (2016). IHC-P ; Human . PubMed: 27619912
  • Qu F  et al. MicroRNA-26a induces osteosarcoma cell growth and metastasis via the Wnt/ß-catenin pathway. Oncol Lett 11:1592-1596 (2016). WB ; Human . PubMed: 26893786
  • Park JW  et al. Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Proc Natl Acad Sci U S A 113:4482-7 (2016). PubMed: 27044116
  • Rennoll SA  et al. The MYC 3' Wnt-Responsive Element Drives Oncogenic MYC Expression in Human Colorectal Cancer Cells. Cancers (Basel) 8:N/A (2016). WB ; Human . PubMed: 27223305
  • Chung SI  et al. Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background. BMC Gastroenterol 16:13 (2016). WB, IHC-P . PubMed: 26821924
  • Boudjadi S  et al. Integrin a1ß1 expression is controlled by c-MYC in colorectal cancer cells. Oncogene 35:1671-8 (2016). WB, ChIP . PubMed: 26096932
  • Alexandrova S  et al. Selection and dynamics of embryonic stem cell integration into early mouse embryos. Development 143:24-34 (2016). PubMed: 26586221
  • Monaghan MG  et al. Endocardial-to-mesenchymal transformation and mesenchymal cell colonization at the onset of human cardiac valve development. Development 143:473-82 (2016). PubMed: 26674310
  • Kluk MJ  et al. MYC Immunohistochemistry to Identify MYC-Driven B-Cell Lymphomas in Clinical Practice. Am J Clin Pathol 145:166-79 (2016). PubMed: 26834124
  • Franco M  et al. A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells. MBio 7:e02231-15 (2016). WB . PubMed: 26838724
  • Agarwal R  et al. Role of immunohistochemistry in the era of genetic testing in MYC-positive aggressive B-cell lymphomas: a study of 209 cases. J Clin Pathol 69:266-70 (2016). PubMed: 26307073
  • Tian-Zhong M  et al. Critical role of Emx2 in the pluripotency - differentiation transition in male gonocytes via regulation of FGF9/NODAL pathway. Reproduction 151:673-81 (2016). PubMed: 27002001
  • Feng D  et al. Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis. Oncotarget 7:64575-64588 (2016). WB ; Human . PubMed: 27602489
  • Kress TR  et al. Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors. Cancer Res 76:3463-72 (2016). PubMed: 27197165
  • Kang J  et al. Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription. Oncotarget 7:48887-48904 (2016). PubMed: 27385002
  • Li X  et al. SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer. Oncotarget 7:12869-84 (2016). IHC . PubMed: 26883200
  • Itkonen HM  et al. Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. Oncotarget 7:12464-76 (2016). WB . PubMed: 26824323
  • Lynch JT  et al. Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen. Oncotarget 7:22128-39 (2016). PubMed: 26989080
  • Hellner K  et al. Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies. EBioMedicine 10:137-49 (2016). PubMed: 27492892
  • Yang CX  et al. MicroRNA-320 regulates the radiosensitivity of cervical cancer cells C33AR by targeting ß-catenin. Oncol Lett 12:4983-4990 (2016). WB . PubMed: 28105205
  • Camarda R  et al. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med 22:427-32 (2016). WB . PubMed: 26950360
  • Liu T  et al. Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma. BMC Cancer 16:790 (2016). PubMed: 27729033
  • Raina K  et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A 113:7124-9 (2016). PubMed: 27274052
  • Swetzig WM  et al. Estrogen receptor alpha (ERa/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. Oncotarget 7:16049-69 (2016). WB . PubMed: 26909605
  • Shen H  et al. Lin28A activates androgen receptor via regulation of c-myc and promotes malignancy of ER-/Her2+ breast cancer. Oncotarget 7:60407-60418 (2016). WB . PubMed: 27494865
  • Feng J  et al. Aortic dissection is associated with reduced polycystin-1 expression, an abnormality that leads to increased ERK phosphorylation in vascular smooth muscle cells. Eur J Histochem 60:2711 (2016). PubMed: 28076932
  • Lee JY  et al. Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells. Dev Reprod 20:171-7 (2016). WB . PubMed: 27660833
  • Tagde A  et al. MUC1-C drives MYC in multiple myeloma. Blood 127:2587-97 (2016). PubMed: 26907633
  • Zhao L  et al. Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering ß-catenin signalling and GADD45G expression. J Cell Mol Med 20:842-54 (2016). WB ; Human . PubMed: 26843424
  • Ferreiro JF  et al. EBV-Positive and EBV-Negative Posttransplant Diffuse Large B Cell Lymphomas Have Distinct Genomic and Transcriptomic Features. Am J Transplant 16:414-25 (2016). IHC-P . PubMed: 26780579
  • Choe JY  et al. MYC overexpression correlates with MYC amplification or translocation, and is associated with poor prognosis in mantle cell lymphoma. Histopathology 68:442-9 (2016). PubMed: 26100211
  • Jin K  et al. Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines. Cancer Prev Res (Phila) 9:324-34 (2016). PubMed: 26851235
  • Harris KL  et al. Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. Oncotarget 7:28947-60 (2016). PubMed: 26959117
  • Chen JL  et al. Suppression of SIK1 by miR-141 in human ovarian cancer cell lines and tissues. Int J Mol Med 37:1601-10 (2016). PubMed: 27081781
  • Song Y  et al. Novel 1, 3-N, O-Spiroheterocyclic compounds inhibit heparanase activity and enhance nedaplatin-induced cytotoxicity in cervical cancer cells. Oncotarget 7:36154-36167 (2016). PubMed: 27166252
  • He T  et al. Methylglyoxal suppresses human colon cancer cell lines and tumor growth in a mouse model by impairing glycolytic metabolism of cancer cells associated with down-regulation of c-Myc expression. Cancer Biol Ther 17:955-65 (2016). PubMed: 27455418
  • Li P  et al. Serum anti-MDM2 and anti-c-Myc autoantibodies as biomarkers in the early detection of lung cancer. Oncoimmunology 5:e1138200 (2016). PubMed: 27467958
  • Bond CE  et al. RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis. Oncotarget 7:70589-70600 (2016). PubMed: 27661107
  • Zhang Y  et al. GDF11 improves tubular regeneration after acute kidney injury in elderly mice. Sci Rep 6:34624 (2016). PubMed: 27703192
  • Zhang Q  et al. Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation. Neoplasia 18:666-673 (2016). PubMed: 27764699
  • Ocampo A  et al. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell 167:1719-1733.e12 (2016). PubMed: 27984723
  • Brasó-Maristany F  et al. PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nat Med 22:1303-1313 (2016). PubMed: 27775704
  • Zhu J  et al. Advanced glycosylation end product promotes forkhead box O1 and inhibits Wnt pathway to suppress capacities of epidermal stem cells. Am J Transl Res 8:5569-5579 (2016). PubMed: 28078027
  • Wen Z  et al. Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells. Int J Mol Med 36:1657-63 (2015). PubMed: 26497016
  • Lee SB  et al. Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. Mol Cell 60:21-34 (2015). IP . PubMed: 26387737
  • Copie-Bergman C  et al. MYC-IG rearrangements are negative predictors of survival in DLBCL patients treated with immunochemotherapy: a GELA/LYSA study. Blood 126:2466-74 (2015). IHC-P ; Human . PubMed: 26373676
  • Tapia G  et al. MYC protein expression is associated with poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system. APMIS 123:596-603 (2015). PubMed: 26010683
  • Wang LL  et al. Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children's Oncology Group study. Br J Cancer 113:57-63 (2015). IHC-P ; Human . PubMed: 26035700
  • González-Prieto R  et al. c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4. Cell Cycle 14:1859-72 (2015). PubMed: 25895136
  • Korangath P  et al. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate. Clin Cancer Res 21:3263-73 (2015). WB ; Human . PubMed: 25813021
  • Bjorklund CC  et al. Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4. Blood Cancer J 5:e354 (2015). IHC ; Human . PubMed: 26430725
  • Chang BS  et al. Collagen complexes increase the efficiency of iPS cells generated using fibroblasts from adult mice. J Reprod Dev 61:145-53 (2015). IF ; Mouse . PubMed: 25740096
  • Meng QB  et al. Overexpression of eukaryotic translation initiation factor 5A2 (EIF5A2) correlates with cell aggressiveness and poor survival in gastric cancer. PLoS One 10:e0119229 (2015). PubMed: 25793713
  • Mamada H  et al. Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc. J Cell Sci 128:790-803 (2015). WB, ICC/IF . PubMed: 25588835
  • Linley A  et al. Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells. Blood 126:1902-10 (2015). PubMed: 26194765
  • Ma L  et al. Trap Effect of Three-Dimensional Fibers Network for High Efficient Cancer-Cell Capture. Adv Healthc Mater 4:838-43 (2015). PubMed: 25645204
  • He TL  et al. The c-Myc-LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer. Med Oncol 32:187 (2015). IHC ; Human . PubMed: 26021472
  • Derenzini E  et al. Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma. Oncotarget 6:6553-69 (2015). IF . PubMed: 25544753
  • Simons BW  et al. A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression. J Pathol 235:478-89 (2015). IHC ; Mouse . PubMed: 25348195
  • Li S  et al. Regulation of c-Myc protein stability by proteasome activator REG?. Cell Death Differ 22:1000-11 (2015). PubMed: 25412630
  • Lee JG & Wu R Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1a in EGFR-mutated lung cancer in vitro and in vivo. Neoplasia 17:190-200 (2015). WB ; Mouse, Human . PubMed: 25748238
  • Carey CD  et al. Molecular classification of MYC-driven B-cell lymphomas by targeted gene expression profiling of fixed biopsy specimens. J Mol Diagn 17:19-30 (2015). IHC ; Human . PubMed: 25468432
  • Xiang Y  et al. Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. J Clin Invest 125:2293-306 (2015). IHC . PubMed: 25915584
  • Zou Y  et al. Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma cells. Mol Med Rep 12:7221-6 (2015). WB, ICC/IF ; Human . PubMed: 26398440
  • Lawson DA  et al. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature 526:131-5 (2015). IHC-P ; Human . PubMed: 26416748
  • Morgado-Palacin L  et al. Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis. Cell Rep 13:712-22 (2015). IHC-P ; Mouse . PubMed: 26489471
  • Siegfried JM  et al. Expression of PAM50 Genes in Lung Cancer: Evidence that Interactions between Hormone Receptors and HER2/HER3 Contribute to Poor Outcome. Neoplasia 17:817-25 (2015). IHC-P ; Human . PubMed: 26678909
  • Sun XX  et al. The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proc Natl Acad Sci U S A 112:3734-9 (2015). PubMed: 25775507
  • Massari F  et al. Prognostic Value of Beta-Tubulin-3 and c-Myc in Muscle Invasive Urothelial Carcinoma of the Bladder. PLoS One 10:e0127908 (2015). IHC-P ; Human . PubMed: 26046361
  • Mahmoud AZ  et al. Scoring of MYC protein expression in diffuse large B-cell lymphomas: concordance rate among hematopathologists. Mod Pathol 28:545-51 (2015). IHC-P ; Human . PubMed: 25431238
  • Barfeld SJ  et al. Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer. Oncotarget 6:12587-602 (2015). WB ; Human . PubMed: 25869206
  • Shokhirev MN  et al. A multi-scale approach reveals that NF-?B cRel enforces a B-cell decision to divide. Mol Syst Biol 11:783 (2015). ICC/IF ; Mouse . PubMed: 25680807
  • Tran D  et al. Functional genomics analysis reveals a MYC signature associated with a poor clinical prognosis in liposarcomas. Am J Pathol 185:717-28 (2015). IHC ; Human . PubMed: 25622542
  • Huang S  et al. Attenuation of microRNA-16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertrophy. J Cell Mol Med 19:608-19 (2015). WB . PubMed: 25583328
  • Kozono D  et al. Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression. Proc Natl Acad Sci U S A 112:E4055-64 (2015). IHC-P ; Mouse . PubMed: 26159421
  • Renaud SJ  et al. OVO-like 1 regulates progenitor cell fate in human trophoblast development. Proc Natl Acad Sci U S A 112:E6175-84 (2015). IHC-P, ICC/IF . PubMed: 26504231
  • Lu TX  et al. Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age. Sci Rep 5:12168 (2015). IHC ; Human . PubMed: 26202875
  • Nowak DG  et al. MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2. Cancer Discov 5:636-51 (2015). PubMed: 25829425
  • Cattoglio C  et al. Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells. Proc Natl Acad Sci U S A 112:E2317-26 (2015). PubMed: 25901318
  • Xie CM  et al. Erbin is a novel substrate of the Sag-ßTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol 209:721-37 (2015). PubMed: 26056141
  • Shi J  et al. Deubiquitinase USP47/UBP64E Regulates ß-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling. Mol Cell Biol 35:3301-11 (2015). PubMed: 26169834
  • Bhusari S  et al. Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice. Toxicol Pathol 43:1114-26 (2015). PubMed: 26289556
  • Amaya CN & Bryan BA Enrichment of the embryonic stem cell reprogramming factors Oct4, Nanog, Myc, and Sox2 in benign and malignant vascular tumors. BMC Clin Pathol 15:18 (2015). PubMed: 26412983
  • Lee KS  et al. c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal Cancer. PLoS One 10:e0139727 (2015). PubMed: 26426996
  • Chen J  et al. Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells. Mar Drugs 13:6259-73 (2015). PubMed: 26445050
  • Venant H  et al. The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo. Mol Cancer Ther 14:2744-52 (2015). PubMed: 26494858
  • Zhu YX  et al. RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2. Blood 125:483-91 (2015). PubMed: 25395420
  • Gajula RP  et al. Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells. Neoplasia 17:16-31 (2015). Human . PubMed: 25622896
  • Kim JS  et al. The prostate cancer TMPRSS2:ERG fusion synergizes with the vitamin D receptor (VDR) to induce CYP24A1 expression-limiting VDR signaling. Endocrinology 155:3262-73 (2014). WB ; Human . PubMed: 24926821
  • Sabò A  et al. Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature 511:488-92 (2014). WB . PubMed: 25043028
  • Wiegering A  et al. E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts. Neoplasia 16:972-81 (2014). WB ; Human . PubMed: 25425971
  • Huang W  et al. C-MYC overexpression predicts aggressive transformation and a poor outcome in mucosa-associated lymphoid tissue lymphomas. Int J Clin Exp Pathol 7:5634-44 (2014). IHC ; Human . PubMed: 25337204
  • Guo H  et al. Post-translational glycoprotein modifications regulate colon cancer stem cells and colon adenoma progression in Apc(min/+) mice through altered Wnt receptor signaling. J Biol Chem 289:31534-49 (2014). PubMed: 25274627
  • Miyata-Takata T  et al. A case of diffuse large B-cell lymphoma transformed from primary duodenal follicular lymphoma. Pathol Int 64:527-32 (2014). PubMed: 25186289
  • Popovic R  et al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation. PLoS Genet 10:e1004566 (2014). WB ; Human . PubMed: 25188243
  • Harashima N  et al. Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-ß-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system. Mol Cancer 13:217 (2014). PubMed: 25227113
  • Turakhia SK  et al. Aggressive B-cell lymphomas with translocations involving BCL6 and MYC have distinct clinical-pathologic characteristics. Am J Clin Pathol 142:339-46 (2014). PubMed: 25125624
  • Molina TJ  et al. Young patients with non-germinal center B-cell-like diffuse large B-cell lymphoma benefit from intensified chemotherapy with ACVBP plus rituximab compared with CHOP plus rituximab: analysis of data from the Groupe d'Etudes des Lymphomes de l'Adulte/lymphoma study association phase III trial LNH 03-2B. J Clin Oncol 32:3996-4003 (2014). IHC-P ; Human . PubMed: 25385729
  • Ferrari de Andrade L  et al. Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanoma. Cancer Res 74:7298-308 (2014). WB ; Mouse . PubMed: 25351955
  • Saborowski M  et al. A modular and flexible ESC-based mouse model of pancreatic cancer. Genes Dev 28:85-97 (2014). WB ; Mouse . PubMed: 24395249
  • Toon CW  et al. Immunohistochemistry for myc predicts survival in colorectal cancer. PLoS One 9:e87456 (2014). IHC-P ; Human . PubMed: 24503701
  • Cho H  et al. RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis. Cancer Discov 4:318-33 (2014). PubMed: 24444712
  • Sanz-Moreno A  et al. Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation. PLoS One 9:e89187 (2014). IF, IHC ; Mouse . PubMed: 24586582
  • Xie Y  et al. p53 expression is a strong marker of inferior survival in de novo diffuse large B-cell lymphoma and may have enhanced negative effect with MYC coexpression: a single institutional clinicopathologic study. Am J Clin Pathol 141:593-604 (2014). Human . PubMed: 24619762
  • Qi WL  et al. Involvement of RbAp48 in erythroid differentiation of murine erythroleukemia cells induced by sodium butyrate. Oncol Lett 7:1785-1789 (2014). WB ; Human . PubMed: 24932233
  • van der Meer R  et al. RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition. Clin Cancer Res 20:3211-21 (2014). PubMed: 24771642
  • Farrell AS  et al. Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer. Mol Cancer Res 12:924-39 (2014). WB, ChIP . PubMed: 24667985
  • Janghorban M  et al. Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer. Proc Natl Acad Sci U S A 111:9157-62 (2014). ChIP . PubMed: 24927563
  • Bellas C  et al. Immunohistochemical and molecular characteristics with prognostic significance in diffuse large B-cell lymphoma. PLoS One 9:e98169 (2014). IHC-P ; Human . PubMed: 24887414
  • Smith SC  et al. CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression. Mod Pathol N/A:N/A (2014). PubMed: 24947144
  • Simeone P  et al. A unique four-hub protein cluster associates to glioblastoma progression. PLoS One 9:e103030 (2014). IHC-P ; Human . PubMed: 25050814
  • Yan LX  et al. MYC expression in concert with BCL2 and BCL6 expression predicts outcome in Chinese patients with diffuse large B-cell lymphoma, not otherwise specified. PLoS One 9:e104068 (2014). IHC-P ; Human . PubMed: 25090026
  • Ceribelli M  et al. Blockade of oncogenic I?B kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. Proc Natl Acad Sci U S A 111:11365-70 (2014). WB . PubMed: 25049379
  • Diefenbacher ME  et al. The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. J Clin Invest 124:3407-18 (2014). WB ; Human . PubMed: 24960159
  • Wang B  et al. N-myc downstream regulated gene 1 acts as a tumor suppressor in ovarian cancer. Oncol Rep 31:2279-85 (2014). PubMed: 24626771
  • Lynch JT  et al. TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell Death Dis 4:e573 (2013). WB, IP ; Human . PubMed: 23559008
  • Horn H  et al. MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. Blood 121:2253-63 (2013). ICC ; Human . PubMed: 23335369
  • Lin WC  et al. Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer. Cancer Res 73:1821-30 (2013). PubMed: 23467612
  • Valera A  et al. ALK-positive large B-cell lymphomas express a terminal B-cell differentiation program and activated STAT3 but lack MYC rearrangements. Mod Pathol N/A:N/A (2013). Human . PubMed: 23599149
  • Padmanabhan A  et al. Protein kinase A regulates MYC protein through transcriptional and post-translational mechanisms in a catalytic subunit isoform-specific manner. J Biol Chem 288:14158-69 (2013). WB . PubMed: 23504319
  • Hu S  et al. MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program. Blood 121:4021-31; quiz 4250 (2013). IHC-P ; Human . PubMed: 23449635
  • Sancho M  et al. Competitive interactions eliminate unfit embryonic stem cells at the onset of differentiation. Dev Cell 26:19-30 (2013). IHC-P . PubMed: 23867226
  • Yi T  et al. Hypoxia-inducible factor-1a (HIF-1a) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions. J Biol Chem 288:18732-42 (2013). Mouse . PubMed: 23667251
  • Pourdehnad M  et al. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A 110:11988-93 (2013). IHC ; Mouse . PubMed: 23803853
  • Chaux A  et al. Dysregulation of the mammalian target of rapamycin pathway in chromophobe renal cell carcinomas. Hum Pathol 44:2323-30 (2013). Human . PubMed: 23953228
  • Hatano K  et al. Residual prostate cancer cells after docetaxel therapy increase the tumorigenic potential via constitutive signaling of CXCR4, ERK1/2 and c-Myc. Mol Cancer Res 11:1088-100 (2013). PubMed: 23788635
  • Rubenstein JL  et al. Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202). J Clin Oncol 31:3061-8 (2013). Human . PubMed: 23569323
  • Munari E  et al. Dysregulation of mammalian target of rapamycin pathway in upper tract urothelial carcinoma. Hum Pathol N/A:N/A (2013). IHC-P ; Human . PubMed: 24074531
  • Pham-Ledard A  et al. Multiple genetic alterations in primary cutaneous large B-cell lymphoma, leg type support a common lymphomagenesis with activated B-cell-like diffuse large B-cell lymphoma. Mod Pathol N/A:N/A (2013). Human . PubMed: 24030746
  • Wang LS  et al. Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. Carcinogenesis N/A:N/A (2013). IHC ; Mouse . PubMed: 24067901
  • Valentino C  et al. Colorimetric in situ hybridization identifies MYC gene signal clusters correlating with increased copy number, mRNA, and protein in diffuse large B-cell lymphoma. Am J Clin Pathol 139:242-54 (2013). IHC-P ; Human . PubMed: 23355209
  • Rosales T  et al. Partition of Myc into immobile vs. mobile complexes within nuclei. Sci Rep 3:1953 (2013). WB . PubMed: 23739641
  • Gurung B  et al. Menin directly represses gli1 expression independent of canonical hedgehog signaling. Mol Cancer Res 11:1215-22 (2013). WB . PubMed: 23928057
  • Chen S  et al. Mechanistic studies for the role of cellular nucleic-acid-binding protein (CNBP) in regulation of c-myc transcription. Biochim Biophys Acta 1830:4769-77 (2013). WB ; Human . PubMed: 23774591
  • Valera A  et al. MYC protein expression and genetic alterations have prognostic impact in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Haematologica 98:1554-62 (2013). IHC, ICC/IF ; Human . PubMed: 23716551
  • Olive V  et al. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife 2:e00822 (2013). WB ; Mouse . PubMed: 24137534
  • Tzankov A  et al. Rearrangements of MYC gene facilitate risk stratification in diffuse large B-cell lymphoma patients treated with rituximab-CHOP. Mod Pathol N/A:N/A (2013). Human . PubMed: 24336156
  • Sanchez-Arévalo Lobo VJ  et al. Dual regulation of Myc by Abl. Oncogene 32:5261-71 (2013). PubMed: 23318434
  • Gajula RP  et al. The twist box domain is required for Twist1-induced prostate cancer metastasis. Mol Cancer Res 11:1387-400 (2013). PubMed: 23982216
  • Chao C  et al. Epstein-Barr virus infection and expression of B-cell oncogenic markers in HIV-related diffuse large B-cell Lymphoma. Clin Cancer Res 18:4702-12 (2012). IHC-P ; Human . PubMed: 22711707
  • Kluk MJ  et al. Immunohistochemical detection of MYC-driven diffuse large B-cell lymphomas. PLoS One 7:e33813 (2012). IHC-P ; Human . PubMed: 22511926
  • Lehmann FM  et al. Humanized c-Myc mouse. PLoS One 7:e42021 (2012). WB ; Human . PubMed: 22860051
  • Tudor CS  et al. c-Myc and EBV-LMP1: two opposing regulators of the HLA class I antigen presentation machinery in epithelial cells. Br J Cancer 106:1980-8 (2012). WB ; Human . PubMed: 22588558
  • Marzi MJ  et al. Differentiation-associated microRNAs antagonize the Rb-E2F pathway to restrict proliferation. J Cell Biol 199:77-95 (2012). WB . PubMed: 23027903
  • Neff T  et al. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc Natl Acad Sci U S A 109:5028-33 (2012). WB . PubMed: 22396593
  • Zhang X  et al. Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression. Proc Natl Acad Sci U S A 109:2790-5 (2012). WB ; Human . PubMed: 21808024
  • Kim CW  et al. Ectopic over-expression of tristetraprolin in human cancer cells promotes biogenesis of let-7 by down-regulation of Lin28. Nucleic Acids Res 40:3856-69 (2012). WB . PubMed: 22210895
  • Ji H  et al. Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation. PLoS One 6:e26057 (2011). PubMed: 22039435
  • Karst AM  et al. Modeling high-grade serous ovarian carcinogenesis from the fallopian tube. Proc Natl Acad Sci U S A 108:7547-52 (2011). PubMed: 21502498
  • Scholer-Dahirel A  et al. Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/{beta}-catenin signaling. Proc Natl Acad Sci U S A 108:17135-40 (2011). IHC-P ; Human . PubMed: 21949247
  • Bruning U  et al. MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol Cell Biol 31:4087-96 (2011). PubMed: 21807897
  • Lorenz A  et al. Severe alterations of cerebellar cortical development after constitutive activation of wnt signaling in granule neuron precursors. Mol Cell Biol 31:3326-38 (2011). IHC-P ; Mouse . PubMed: 21690300
  • Steininger A  et al. Genomic loss of the putative tumor suppressor gene E2A in human lymphoma. J Exp Med 208:1585-93 (2011). IHC-P ; Human . PubMed: 21788410
  • Seitz V  et al. Deep Sequencing of MYC DNA-Binding Sites in Burkitt Lymphoma. PLoS One 6:e26837 (2011). WB ; Human . PubMed: 22102868
  • Challagundla KB  et al. Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Mol Cell Biol 31:4007-21 (2011). Human . PubMed: 21807902
  • Pagán B  et al. Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model. World J Gastroenterol 17:4858-66 (2011). IHC-P ; Rat . PubMed: 22171126
  • Ren Y  et al. Critical role of Shp2 in tumor growth involving regulation of c-Myc. Genes Cancer 1:994-1007 (2010). IHC-P ; Human . PubMed: 21442024
  • Escamilla-Powers JR  et al. The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity. J Biol Chem 285:4847-58 (2010). IP ; Human . PubMed: 20008325
  • Rohan JN & Weigel NL 1Alpha,25-dihydroxyvitamin D3 reduces c-Myc expression, inhibiting proliferation and causing G1 accumulation in C4-2 prostate cancer cells. Endocrinology 150:2046-54 (2009). PubMed: 19164469
  • Silva MM  et al. Characterization of reactive stroma in prostate cancer: involvement of growth factors, metalloproteinase matrix, sexual hormones receptors and prostatic stem cells. Int Braz J Urol 41:849-58 (0). PubMed: 26689510

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