Anti-Blood Group Lewis y抗体[F3] (ab3359)
Key features and details
- Mouse monoclonal [F3] to Blood Group Lewis y
- Reacts with: Human
- Isotype: IgM
概述
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产品名称
Anti-Blood Group Lewis y抗体[F3]
参阅全部 Blood Group Lewis y 一抗 -
描述
小鼠单克隆抗体[F3] to Blood Group Lewis y -
宿主
Mouse -
特异性
This antibody belongs to the BG-8 group of murine monoclonal antibodies and is specific against the Lewis y (Type 2 Chain) antigen. -
种属反应性
与反应: Human -
免疫原
SK-LU-3 lung cancer cell line (Human).
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阳性对照
- Colon adenocarcinoma (human).
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常规说明
Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis a, Lewis b, Lewis x, Lewis y, and precursor type 1 chain antigens. Lewis y (type 2 chain) antigen is a difucosylated tetrasaccharide found on the Type 2 blood group oligosaccharides of glycolipids and glycoproteins. It is expressed in large bowel tumors and colorectal carcinomas. It may be useful in the classification of human renal and bladder tumors. The Lewis y antigen has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular carcinoma and breast cancer.
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性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
纯度
Ammonium Sulphate Precipitation -
Primary antibody说明
Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis a, Lewis b, Lewis x, Lewis y, and precursor type 1 chain antigens. Lewis y (type 2 chain) antigen is a difucosylated tetrasaccharide found on the Type 2 blood group oligosaccharides of glycolipids and glycoproteins. It is expressed in large bowel tumors and colorectal carcinomas. It may be useful in the classification of human renal and bladder tumors. The Lewis y antigen has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular carcinoma and breast cancer. -
克隆
单克隆 -
克隆编号
F3 -
同种型
IgM -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
靶标
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别名
- Lewis Y blood group antibody
实验方案
文献 (21)
ab3359 被引用在 21 文献中.
- Li C et al. Association between the ABO blood group and primary knee osteoarthritis: A case-control study. J Orthop Translat 21:129-135 (2020). PubMed: 32309138
- Liu J et al. Co-expression of Lewis y antigen and CD147 in epithelial ovarian cancer is correlated with malignant progression and poor prognosis. Int J Mol Med 43:1687-1698 (2019). PubMed: 30816446
- Blanas A et al. Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells. Glycobiology 29:137-150 (2019). PubMed: 30476078
- Almand EA et al. Characterization of human norovirus binding to gut-associated bacterial ligands. BMC Res Notes 12:607 (2019). PubMed: 31547886
- Purohit S et al. Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins. Nat Commun 9:258 (2018). PubMed: 29343722
