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Microbiology Organism Virus RNA Virus ssRNA positive strand virus HCV

生物素抗丙型肝炎病毒Core Antigen抗体[1F6] (ab2587)

  • Datasheet
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Key features and details

  • Biotin Mouse monoclonal [1F6] to Hepatitis C Virus Core Antigen
  • Suitable for: IP, ELISA
  • Reacts with: Hepatitis C virus
  • Conjugation: Biotin
  • Isotype: IgG2a

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概述

  • 产品名称

    生物素抗丙型肝炎病毒Core Antigen抗体[1F6]
    参阅全部 Hepatitis C Virus Core Antigen 一抗
  • 描述

    生物素小鼠单克隆抗体[1F6] to丙型肝炎病毒Core Antigen
  • 宿主

    Mouse
  • 偶联物

    Biotin
  • 特异性

    This antibody is specific for Hepatitis C Core Antigen.
  • 经测试应用

    适用于: IP, ELISAmore details
  • 种属反应性

    与反应: Hepatitis C virus
  • 免疫原

    Synthetic peptide, corresponding to amino acids 80-120 of Hepatitis C Core Antigen.

  • 表位

    This antibody recognises amino acid residues 80-120 of Hepatitis C Core Antigen.
  • 常规说明

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液

    pH: 7.20
    Preservative: 0.01% Sodium azide
  • Concentration information loading...
  • 克隆

    单克隆
  • 克隆编号

    1F6
  • 骨髓瘤

    unknown
  • 同种型

    IgG2a
  • 轻链类型

    unknown
  • 研究领域

    • Microbiology
    • Organism
    • Virus
    • RNA Virus
    • ssRNA positive strand virus
    • HCV
    • Microbiology
    • Organism
    • Virus
    • RNA Virus
    • ssRNA positive strand virus
    • Hepatitis A/C/E/G

相关产品

  • Isotype control

    • Biotin Mouse IgG2a, kappa [MOPC-173] - Isotype Control (ab18454)

应用

Our Abpromise guarantee covers the use of ab2587 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.

靶标

  • 相关性

    The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • 细胞定位

    Endoplasmic reticulum
  • 数据库链接

    • SwissProt: P26664 Hepatitis C virus
    • SwissProt: P29846 Hepatitis C virus
    • 别名

      • Core protein p21 antibody
      • HCV core antigen antibody
      • HCV core protein antibody
      • Hepatitis C Virus core protein antibody

    实验方案

    • Immunoprecipitation protocols

    Click here to view the general protocols

    数据表及文件

    • Datasheet
  • 文献 (1)

    发表研究结果有使用 ab2587?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab2587 被引用在 1 文献中.

    • Yang S  et al. Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity. Redox Biol 3:63-71 (2014). WB ; Rat . PubMed: 25462067

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