Anti-beta 2 Microglobulin抗体(ab6608)
Key features and details
- Rabbit polyclonal to beta 2 Microglobulin
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-beta 2 Microglobulin抗体
参阅全部 beta 2 Microglobulin 一抗 -
描述
兔多克隆抗体to beta 2 Microglobulin -
宿主
Rabbit -
种属反应性
与反应: Human -
免疫原
b 2-Microglobulin [Human Urine]
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常规说明
The antibody reacts with b2-microglobulin isolated from human urine showing a 12.8 kDa band under non-reducing condition of SDS-PAGE.Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.01% Sodium azide
Constituents: 0.878% Sodium chloride, 0.424% Potassium phosphate -
Concentration information loading...
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纯度
IgG fraction -
纯化说明
This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum as well as purified and partially purified b 2-Microglobulin [Human Urine]. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
靶标
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功能
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. -
疾病相关
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. -
序列相似性
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain. -
翻译后修饰
Glycation of Ile-21 is observed in long-term hemodialysis patients. -
细胞定位
Secreted. Detected in serum and urine. - Information by UniProt
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数据库链接
- Entrez Gene: 567 Human
- Omim: 109700 Human
- SwissProt: P61769 Human
- Unigene: 534255 Human
- Unigene: 702947 Human
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别名
- B2M antibody
- B2MG_HUMAN antibody
- Beta 2 microglobin antibody
see all
实验方案
文献 (4)
ab6608 被引用在 4 文献中.
- Kotsiou E et al. Dimerization of soluble disulfide trap single-chain major histocompatibility complex class I molecules dependent on Peptide binding affinity. Antioxid Redox Signal 15:635-44 (2011). WB ; Human . PubMed: 21050141
- Vecchi C et al. Huh-7: a human "hemochromatotic" cell line. Hepatology 51:654-9 (2010). ICC/IF ; Human . PubMed: 20017200
- Pi M et al. GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. PLoS ONE 3:e3858 (2008). WB ; Human . PubMed: 19050760
- Yalcin, A and Cetin, M Electrophoretic Separation of Urine Proteins of Healthy Dogs and Dogs with Nephropathy and Detection of Some Urine Proteins of Dogs Using Immunoblotting. Revue Med. Vet. 155:104-112 (2004). PubMed: