Key features and details
- Rabbit polyclonal to BCOR
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
Concentration information loading...
纯度Immunogen affinity purified
Our Abpromise guarantee covers the use of ab129777 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 192 kDa.|
|IHC-P||1/50 - 1/100.|
功能Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
疾病相关Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:300166]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).
序列相似性Belongs to the BCOR family.
Contains 3 ANK repeats.
- Information by UniProt
- 5830466J11Rik antibody
- 8430401K06Rik antibody
- ANOP 2 antibody
All lanes : Anti-BCOR antibody (ab129777) at 1/500 dilution
Lane 1 : COLO cell extract
Lane 2 : COLO cell extract with immunizing peptide
Predicted band size: 192 kDa
ab129777, at 1/50 dilution, staining BCOR in paraffin-embedded Human breast carcinoma tissue by immunohistochemistry in the presence (right panel) or absence (left panel) of immunizing peptide.