概述

  • 产品名称
  • 描述
    兔多克隆抗体to Axin 2
  • 宿主
    Rabbit
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Human
  • 免疫原

    Synthetic peptide within Human Axin 2 aa 350-400 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    PHFPRTHRLPK EMTPVEPATF AAELISRLEK LKLELESRHS LEERLQQIRE


    Database link: Q9Y2T1

  • 阳性对照
    • Rat brain and rat lymph node tissues.

性能

应用

Our Abpromise guarantee covers the use of ab218023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500.

靶标

  • 功能
    Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
  • 组织特异性
    Expressed in brain and lymphoblast.
  • 疾病相关
    Defects in AXIN2 are involved in colorectal cancer (CRC) [MIM:114500]. They appear to be specifically associated with defective mismatch repair.
    Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]. Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
  • 序列相似性
    Contains 1 DIX domain.
    Contains 1 RGS domain.
  • 结构域
    The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.
  • 翻译后修饰
    Probably phosphorylated by GSK3B and dephosphorylated by PP2A.
    ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.
    Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Axil antibody
    • Axin like protein antibody
    • Axin-2 antibody
    • Axin-like protein antibody
    • Axin2 antibody
    • AXIN2_HUMAN antibody
    • Axis inhibition protein 2 antibody
    • Conductin antibody
    • DKFZp781B0869 antibody
    • MGC10366 antibody
    • MGC126582 antibody
    see all

图片

  • Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat lymph node tissue labeling Axin 2 with ab218023 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat brain tissue labeling Axin 2 with ab218023 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

文献

ab218023 has not yet been referenced specifically in any publications.

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