存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
存储溶液Preservative: 0.09% Sodium azide
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纯度Ammonium Sulphate Precipitation
纯化说明ab71264 is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Our Abpromise guarantee covers the use of ab71264 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/50 - 1/100. Detects a band of approximately 58 kDa (predicted molecular weight: 58 kDa).|
|IHC-P||1/10 - 1/50.|
功能Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
组织特异性Brain, placenta and gonads.
疾病相关Defects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity.
Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:107910]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.
序列相似性Belongs to the cytochrome P450 family.
- Information by UniProt
- ARO antibody
- ARO1 antibody
- Aromatase antibody
Anti-Aromatase antibody - C-terminal (ab71264) at 1/60 dilution + Jurkat cell line lysate at 35 µg
Predicted band size: 58 kDa
Observed band size: 58 kDa
Additional bands at: 36 kDa. We are unsure as to the identity of these extra bands.
ab71264 at 1/50 dilution staining Aromatase -C- terminal in human placenta tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections). A peroxidase conjugated secondary antibody was used followed by DAB staining.