Apamin,blocker of small conductance Ca2+-activated K+ channels (ab120268)
Key features and details
- Blocker of small conductance Ca2+-activated K+ channels
- CAS Number: 24345-16-2
- Soluble in water
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Apamin,blocker of small conductance Ca2+-activated K+ channels -
描述
Blocker of small conductance Ca2+-activated K+ channels -
别名
- SK channel
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生物学描述
Peptide neurotoxin that naturally occurs in Apis mellifera bee venom. Blocks small conductance Ca2+ activated K+ channels (SK). Selective for KCa2.1-2.3 (SK1-3) isoforms. Blocks hSK1, rSK2 and liver rSK3 (IC50 values are 8 nM, 83 pM and 0.6 nM, respectively).
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CAS编号
24345-16-2 -
化学结构
性能
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分子量
2027.35 -
分子式
C79H131N31O24S4 -
序列
CNCKAPETALCARRCQQH (Modifications: C-terminal amide; Disulfide bonds: 1-11, 3-15) -
PubChem识别号
16218850 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
图片
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2D chemical structure image of ab120268, Apamin, blocker of small conductance Ca2+-activated K+ channels
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Confocal images from a transcardially-fixed rat brain previously injected with blockers (left-side dorsal striatum, Left DMS) and blockers plus apamin (right-side dorsal striatum, Right DMS) showing double staining for ChAT and p-Ser240–244-S6rp. Top panels are low-magnification images showing several cholinergic interneurons in the same focal plane. Bottom panels are higher magnification images showing p-S6rp signal intensity in CINs from the left (blockers) and right (blockers + apamin) striata of the same animal. Insets show corresponding ChAT staining.
Bertran-Gonzalez J et al., PloS one., 7(12): e53195. Fig 6B.; doi: 10.1371/journal.pone.0053195
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (11)
ab120268 被引用在 11 文献中.
- Viet NM et al. Heterogeneity of intrinsic plasticity in cerebellar Purkinje cells linked with cortical molecular zones. iScience 25:103705 (2022). PubMed: 35059609
- Zhang X et al. Effects of KCa channels on biological behavior of trophoblasts. Open Life Sci 17:1043-1052 (2022). PubMed: 36118166
- Zak M et al. Augmented KCa2.3 Channel Feedback Regulation of Oxytocin Stimulated Uterine Strips from Nonpregnant Mice. Int J Mol Sci 22:N/A (2021). PubMed: 34948381
- Sahu G et al. Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability. Cell Rep 28:2427-2442.e6 (2019). PubMed: 31461656
- Wang M et al. Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide. Biomed Res Int 2018:2925985 (2018). PubMed: 29511675