Anti-ANKRD1抗体(ab64963)
Key features and details
- Rabbit polyclonal to ANKRD1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ANKRD1抗体
参阅全部 ANKRD1 一抗 -
描述
兔多克隆抗体to ANKRD1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Synthetic peptide (Human) from an internal region
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab64963于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).
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说明 |
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WB
1/500 - 1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa). |
靶标
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功能
May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. -
组织特异性
Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells. -
疾病相关
Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) [MIM:106700]. TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births. -
序列相似性
Contains 5 ANK repeats. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 27063 Human
- Entrez Gene: 107765 Mouse
- Omim: 609599 Human
- SwissProt: Q15327 Human
- SwissProt: Q9CR42 Mouse
- Unigene: 448589 Human
- Unigene: 10279 Mouse
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别名
- ALRP antibody
- ANKR1_HUMAN antibody
- ANKRD 1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab64963 被引用在 3 文献中.
- Benkner A et al. Riociguat attenuates the changes in left ventricular proteome and microRNA profile after experimental aortic stenosis in mice. Br J Pharmacol 179:4575-4592 (2022). PubMed: 35751875
- Kempton A et al. Altered regulation of cardiac ankyrin repeat protein in heart failure. Heliyon 4:e00514 (2018). PubMed: 29560432
- Band M et al. The muscle ankyrin repeat proteins are hypoxia-sensitive: in vivo mRNA expression in the hypoxia-tolerant blind subterranean mole rat, Spalax ehrenbergi. J Mol Evol 70:1-12 (2010). WB ; Rat, Other species . PubMed: 19967343