Anti-Angiopoietin-like 4/ANGPTL4抗体(ab115798)
Key features and details
- Rabbit polyclonal to Angiopoietin-like 4/ANGPTL4
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
-
产品名称
Anti-Angiopoietin-like 4/ANGPTL4抗体
参阅全部 Angiopoietin-like 4/ANGPTL4 一抗 -
描述
兔多克隆抗体to Angiopoietin-like 4/ANGPTL4 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human Angiopoietin-like 4/ANGPTL4 (internal sequence).
(Peptide available asab123817) -
阳性对照
- Breast cancer tissue.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservatives: 0.025% Thimerosal (merthiolate), 0.025% Sodium azide
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate -
Concentration information loading...
-
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab115798于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 45 kDa.
The detection limit for Angiopoietin-like 4/ANGPTL4 is approximately 2.5ng/lane under non-reducing and reducing conditions. |
说明 |
---|
WB
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 45 kDa. The detection limit for Angiopoietin-like 4/ANGPTL4 is approximately 2.5ng/lane under non-reducing and reducing conditions. |
靶标
-
功能
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. -
组织特异性
Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. -
序列相似性
Contains 1 fibrinogen C-terminal domain. -
翻译后修饰
N-glycosylated. -
细胞定位
Secreted. Secreted > extracellular space > extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4. - Information by UniProt
-
数据库链接
- Entrez Gene: 51129 Human
- Omim: 605910 Human
- SwissProt: Q9BY76 Human
- Unigene: 9613 Human
-
别名
- Angiopoietin like 4 antibody
- Angiopoietin related protein 4 antibody
- Angiopoietin-like protein 4 antibody
see all
图片
-
All lanes : Anti-Angiopoietin-like 4/ANGPTL4 antibody (ab115798)
Lane 1 : Human Placenta Tissue Lysate at 50 µg
Lane 2 : SMMC Whole Cell Lysate at 40 µg
Lane 3 : HeLa Whole Cell Lysate at 40 µg
Predicted band size: 45 kDa -
All lanes : Anti-Angiopoietin-like 4/ANGPTL4 antibody (ab115798)
Lane 1 : Smmc Whole Cell Lysate
Lane 2 : A549 Whole Cell Lysate
Lane 3 : U87 Whole Cell Lysate
Lane 4 : 293T Whole Cell Lysate
Lane 5 : SGC Whole Cell Lysate
Predicted band size: 45 kDa
数据表及文件
-
SDS download
-
Datasheet download
文献 (5)
ab115798 被引用在 5 文献中.
- Cai YC et al. ANGPTL4 overexpression inhibits tumor cell adhesion and migration and predicts favorable prognosis of triple-negative breast cancer. BMC Cancer 20:878 (2020). PubMed: 32928141
- Kamermans A et al. Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity. Front Immunol 10:950 (2019). PubMed: 31130950
- Chellan B et al. Enzyme-modified non-oxidized LDL (ELDL) induces human coronary artery smooth muscle cell transformation to a migratory and osteoblast-like phenotype. Sci Rep 8:11954 (2018). PubMed: 30097618
- Li B et al. TGF-ß2-induced ANGPTL4 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone. Oncotarget 8:54966-54977 (2017). PubMed: 28903395
- Florea V et al. c-Myc Is Essential to Prevent Endothelial Pro-Inflammatory Senescent Phenotype. PLoS One 8:e73146 (2013). WB . PubMed: 24039874