Anti-Angiogenin抗体(ab139947)
Key features and details
- Rabbit polyclonal to Angiogenin
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-Angiogenin抗体
参阅全部 Angiogenin 一抗 -
描述
兔多克隆抗体to Angiogenin -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat
预测可用于: Mouse -
免疫原
Synthetic peptide corresponding to Human Angiogenin (internal sequence). The immunogen is located within amino acids 70 - 120. 15 amino acid synthetic peptide.
Database link: P03950 -
阳性对照
- Rat liver tissue lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store undiluted. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab139947于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 17 kDa.
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说明 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 17 kDa. |
靶标
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功能
May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. -
组织特异性
Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. -
疾病相关
Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy. -
序列相似性
Belongs to the pancreatic ribonuclease family. -
发展阶段
Low level expression in the developing fetus, increased in the neonate, and maximal in the adult. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 11727 Mouse
- Entrez Gene: 497229 Rat
- SwissProt: P21570 Mouse
- Unigene: 202665 Mouse
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别名
- ALS9 antibody
- AMYOTROPHIC LATERAL SCLEROSIS antibody
- ANG 1 antibody
see all
图片
实验方案
数据表及文件
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Datasheet download
文献 (4)
ab139947 被引用在 4 文献中.
- Tu E et al. Dl-3-n-Butylphthalide promotes neovascularization and neurological recovery in a rat model of intracerebral hemorrhage. BMC Neurosci 21:24 (2020). PubMed: 32471341
- Pan L et al. ZNF750 inhibited the malignant progression of oral squamous cell carcinoma by regulating tumor vascular microenvironment. Biomed Pharmacother 105:566-572 (2018). WB . PubMed: 29890464
- Wei HY et al. Puerarin regulates neovascular glaucoma through pigment epithelium-derived growth factor-induced NF-?B signaling pathway. Mol Med Rep 17:7866-7874 (2018). PubMed: 29620183
- Liu S et al. Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development. Am J Physiol Lung Cell Mol Physiol 306:L1104-16 (2014). PubMed: 24793170