beta-Amyloid多肽(1-42) (human) (ab120301)
Key features and details
- beta-Amyloid (1-42) protein fragment. Implicated in Alzheimer's disease.
- CAS Number: 107761-42-2
Solubility is batch-dependent. Please refer to the Protocol Booklet and the batch-specific CoA for more information.
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
beta-Amyloid多肽(1-42) (human) -
描述
beta-Amyloid (1-42)蛋白片段. Implicated in Alzheimer's disease. -
别名
- AB42
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CAS编号
107761-42-2 -
化学结构
性能
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分子量
4514.08 -
分子式
C203H311N55O60S -
序列
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA -
PubChem识别号
57339251 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Solubility is batch-dependent. Please refer to the Protocol Booklet and the batch-specific CoA for more information.
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处理
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Solvents listed may be unsuitable for use in biological experiments. These solvents are intended to enable solubilisation and mixing of components. We recommend that biologically unsuitable solvents are removed prior to solubilisation in experimental media.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Amyloid β (1-42) human peptide should be initially dissolved according to this method: Add a small amount of 1% NH4OH directly to the lyophilized solid (50-100 μl should be sufficient for 1mg of peptide) Dilute to a concentration of 1mg/ml or less with your buffer. Vortex gently to mix (less than 1 minute). The peptide cannot be stored long term in 1% NH4OH, therefore it is important to immediately dilute the NH4OH/peptide solution with PBS or other buffer to a concentration of 1 mg/ml.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
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文献 (32)
ab120301 被引用在 32 文献中.
- Khodabakhsh P et al. MicroRNA-140-5p inhibitor attenuates memory impairment induced by amyloid-ß oligomer in vivo possibly through Pin1 regulation. CNS Neurosci Ther 29:91-103 (2023). PubMed: 36184817
- Rahmati M et al. Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer's disease. Sci Rep 13:2535 (2023). PubMed: 36781881
- Li R et al. Plasmalogen Improves Memory Function by Regulating Neurogenesis in a Mouse Model of Alzheimer's Diseases. Int J Mol Sci 24:N/A (2023). PubMed: 37569610
- Nedaei H et al. The calcium-free form of atorvastatin inhibits amyloid-ß(1-42) aggregation in vitro. J Biol Chem 298:101662 (2022). PubMed: 35104501
- Pedicone C et al. Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia. iScience 25:104170 (2022). PubMed: 35465359