Amiloride hydrochloride,eNaC blocker (ab120281)
Key features and details
- eNaC blocker
- CAS Number: 2016-88-8
- Purity: > 99%
- Soluble in water to 10 mM (with heating) and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
Amiloride hydrochloride,eNaC blocker -
描述
eNaC blocker -
生物学描述
Epithelial sodium channel (eNaC) blocker. At higher concentrations, blocks the Na+/H+ exchange pathway. Also blocks transient reception potential cation (TRPC6 and TRPP3) channels.
-
纯度
> 99% -
CAS编号
2016-88-8 -
化学结构
性能
-
化学名称
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride -
分子量
266.09 -
分子式
C6H8ClN7O.HCl -
PubChem识别号
16230 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 10 mM (with heating) and in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
Cl.Clc1nc(C(=O)NC(=N)N)c(N)nc1N -
来源
Synthetic
-
研究领域
- Epigenetics and Nuclear Signaling
- Transcription
- Domain Families
- HLH / Leucine Zipper
- Helix-Turn-Helix
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Epigenetics and Nuclear Signaling
- Chromatin Modifying Enzymes
- Acetylation
- HDACs
- Class II / Hda1 Class
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120281 被引用在 3 文献中.
- Shi JM et al. Endocytosis Is a Key Mode of Interaction between Extracellular β-Amyloid and the Cell Membrane. Biophys J 122:1568-1569 (2023). PubMed: 36948190
- Shi JM et al. Endocytosis Is a Key Mode of Interaction between Extracellular ß-Amyloid and the Cell Membrane. Biophys J 119:1078-1090 (2020). PubMed: 32857960
- Jullié D et al. Recycling endosomes undergo rapid closure of a fusion pore on exocytosis in neuronal dendrites. J Neurosci 34:11106-18 (2014). PubMed: 25122907