Anti-Alpha B Crystallin (phospho S45)抗体(ab5598)

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Western blot - Anti-Alpha B Crystallin (phospho S45) antibody (ab5598)

    Key features and details

    • Rabbit polyclonal to Alpha B Crystallin (phospho S45)
    • Suitable for: WB
    • Reacts with: Recombinant fragment
    • Isotype: IgG

    概述

    • 产品名称

      Anti-Alpha B Crystallin (phospho S45)抗体
      参阅全部 Alpha B Crystallin 一抗

    • 描述

      兔多克隆抗体to Alpha B Crystallin (phospho S45)

    • 宿主

      Rabbit

    • 经测试应用

      适用于: WBmore details

    • 种属反应性

      与反应: Recombinant fragment
      预测可用于: Sheep, Rabbit, Hamster, Pig, Cynomolgus monkey

    • 免疫原

      Synthetic peptide corresponding to Human Alpha B Crystallin aa 1-100 (phospho S45).

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab5598于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    WB
    Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa.
    说明
    WB
    Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa.

    靶标

    • 功能

      May contribute to the transparency and refractive index of the lens.

    • 组织特异性

      Lens as well as other tissues.

    • 疾病相关

      Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients.

    • 序列相似性

      Belongs to the small heat shock protein (HSP20) family.

    • 细胞定位

      Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
    • Information by UniProt

    • 数据库链接

      • 别名

        • AACRYA antibody
        • Alpha B crystallin antibody
        • Alpha crystallin B chain antibody
        • Alpha(B)-crystallin antibody
        • Alpha-crystallin B chain antibody
        • CRYA2 antibody
        • Cryab antibody
        • CRYAB_HUMAN antibody
        • Crystallin alpha B antibody
        • Crystallin alpha polypeptide 2 antibody
        • CTPP2 antibody
        • Heat shock 20 kD like protein antibody
        • Heat shock protein beta 5 antibody
        • Heat shock protein beta-5 antibody
        • HspB5 antibody
        • Renal carcinoma antigen NY REN 27 antibody
        • Renal carcinoma antigen NY-REN-27 antibody
        • Rosenthal fiber component antibody
        see all

      图片

      • Western blot - Anti-Alpha B Crystallin (phospho S45) antibody (ab5598)
        Western blot - Anti-Alpha B Crystallin (phospho S45) antibody (ab5598)
        Western blot of recombinant bovine phospho-alpha-B crystallin (Ser45) using ab5598. Lane 1 is phospho-alpha-B crystallin (Ser45) and lane 2 is unphosphorylated alpha-B crystallin.

      文献 (2)

      发表研究结果有使用 ab5598？请让我们知道，以便我们可以引用本数据表中的参考文章。

      ab5598 被引用在 2 文献中.

      • Kuipers HF  et al. Phosphorylation of aB-crystallin supports reactive astrogliosis in demyelination. Proc Natl Acad Sci U S A 114:E1745-E1754 (2017). PubMed: 28196893
      • Tanito M  et al. Diagnostic Western blot for lens-specific proteins in aqueous fluid after traumatic lens-induced uveitis. Jpn J Ophthalmol 53:436-9 (2009). PubMed: 19763765

      客户评价及客户问答

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      Question

      Dear sirs, our lab is currently using phospho alphaB-crystallin Abs but we are seriously considering to switch to different ones. Since we plan to spend a lot of money in these and other Abs, I would like to know if there could be any possibility to test the aB polyclonal Abs (total and 19/45/59 phosphorylated forms) before placing an order.

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      Answer

      Thank you for your enquiry. We do not routinely offer free or trial sized samples for testing purposes. Our policy at Abcam is that if an antibody does not work as specified on the datasheet, we will offer a replacement or reimbursement. Should you decide to test an antibody in an application for which we do not have any information, please let us know how you get on and in return we will award you 50 points with the Abcam Loyalty Scheme which can be redeemed on a number of rewards.

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