Anti-alpha 1 Glycine Receptor/GLRA1抗体(ab166935)
Key features and details
- Goat polyclonal to alpha 1 Glycine Receptor/GLRA1
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-alpha 1 Glycine Receptor/GLRA1抗体
参阅全部 alpha 1 Glycine Receptor/GLRA1 一抗 -
描述
山羊多克隆抗体to alpha 1 Glycine Receptor/GLRA1 -
宿主
Goat -
特异性
The immunizing peptide represents part of the cytoplasmic domain. ab166935 is not expected to cross-react with other glycine receptor alpha proteins. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse
预测可用于: Cow, Dog, Human, Pig -
免疫原
Synthetic peptide corresponding to Rat alpha 1 Glycine Receptor/GLRA1 aa 373-386 (internal sequence).
Sequence:CLQAKDGISVKGAN
Database link: NP_037265.1 -
阳性对照
- Mouse and Rat testis lysates.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab166935 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab166935于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 52 kDa.
1 hour primary incubation is recommended for this product. |
说明 |
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WB
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 52 kDa. 1 hour primary incubation is recommended for this product. |
靶标
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功能
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). -
疾病相关
Defects in GLRA1 are a cause of startle disease (STHE) [MIM:149400]; also known as hereditary hyperekplexia or congenital stiff-person syndrome. STHE is a genetically heterogeneous neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Inheritance can be autosomal dominant or recessive. -
序列相似性
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily. -
细胞定位
Cell junction > synapse > postsynaptic cell membrane. Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 281783 Cow
- Entrez Gene: 489172 Dog
- Entrez Gene: 2741 Human
- Entrez Gene: 14654 Mouse
- Omim: 138491 Human
- SwissProt: P57695 Cow
- SwissProt: P23415 Human
- SwissProt: Q64018 Mouse
see all -
别名
- GLRA1 antibody
- GLRA1_HUMAN antibody
- Glycine receptor 48 kDa subunit antibody
see all
图片
数据表及文件
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Datasheet download
文献 (1)
ab166935 被引用在 1 文献中.
- Qi M et al. Transient Receptor Potential Vanilloid 4 Activation-Induced Increase in Glycine-Activated Current in Mouse Hippocampal Pyramidal Neurons. Cell Physiol Biochem 45:1084-1096 (2018). PubMed: 29439248