Anti-ADAMTS4抗体(ab84792)
Key features and details
- Rabbit polyclonal to ADAMTS4
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-ADAMTS4抗体
参阅全部 ADAMTS4 一抗 -
描述
兔多克隆抗体to ADAMTS4 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide from the C-terminal of Human ADAMTS4 (NM_005099).
-
阳性对照
- IHC-P: Human brain tissue. WB: Human fetal brain lysates.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide -
Concentration information loading...
-
纯度
Protein A/G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab84792于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/200 - 1/500. Detects a band of approximately 90 kDa (predicted molecular weight: 90 kDa).
|
|
IHC-P |
1/100 - 1/500.
|
说明 |
---|
WB
1/200 - 1/500. Detects a band of approximately 90 kDa (predicted molecular weight: 90 kDa). |
IHC-P
1/100 - 1/500. |
靶标
-
功能
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-
-Ala-393' site. -
组织特异性
Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. -
序列相似性
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 1 TSP type-1 domain. -
结构域
The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. -
翻译后修饰
The precursor is cleaved by a furin endopeptidase. -
细胞定位
Secreted > extracellular space > extracellular matrix. - Information by UniProt
-
数据库链接
- Entrez Gene: 9507 Human
- Omim: 603876 Human
- SwissProt: O75173 Human
- Unigene: 211604 Human
-
别名
- A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody
- A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 4 antibody
- A disintegrin like and metalloprotease with thrombospondin type 1 motif 4 antibody
see all
图片
数据表及文件
-
SDS download
-
Datasheet download
文献 (11)
ab84792 被引用在 11 文献中.
- Feng M et al. Circ_0020093 ameliorates IL-1ß-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b. Mol Cell Biochem N/A:N/A (2021). PubMed: 34046827
- Zhao K et al. Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration. Cell Prolif 54:e12941 (2021). PubMed: 33111436
- Liu W et al. INSR mediated by transcription factor KLF4 and DNA methylation ameliorates osteoarthritis progression via inactivation of JAK2/STAT3 signaling pathway. Am J Transl Res 12:7953-7967 (2020). PubMed: 33437372
- Chen J et al. Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages. Cell Physiol Biochem 46:1693-1703 (2018). PubMed: 29694979
- Yang B et al. IL-1β-induced miR-34a up-regulation inhibits Cyr61 to modulate osteoarthritis chondrocyte proliferation through ADAMTS-4. J Cell Biochem 119:7959-7970 (2018). PubMed: 29236314