Anti-ADAMTS12抗体(ab45041)
Key features and details
- Rabbit polyclonal to ADAMTS12
- Suitable for: WB
- Reacts with: Mouse, African green monkey
- Isotype: IgG
概述
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产品名称
Anti-ADAMTS12抗体
参阅全部 ADAMTS12 一抗 -
描述
兔多克隆抗体to ADAMTS12 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, African green monkey -
免疫原
Synthetic peptide based on the propeptide region of Human ADAMTS12.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.05% Sodium azide
Constituent: 50% Glycerol -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab45041于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
说明 |
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靶标
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相关性
This protein is a disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12), which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin like domain, and a thrombospondin type 1 (TS 1) motif. Individual members of this family differ in the number of C terminal TS 1 motifs, and some have unique C terminal domains. The enzyme encoded by this gene contains 8 TS 1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. -
细胞定位
Secreted -
数据库链接
- Entrez Gene: 239337 Mouse
- SwissProt: Q3UM66 Mouse
- SwissProt: Q3UXR3 Mouse
- SwissProt: Q811B3 Mouse
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别名
- A disintegrin and metalloproteinase with thrombospondin motifs 12 antibody
- A disintegrin like and metalloprotease with thrombospondin type 1 motif 12 antibody
- ADAM metallopeptidase with thrombospondin type 1 motif 12 antibody
- ADAM TS 12 antibody
图片
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All lanes : Anti-ADAMTS12 antibody (ab45041) at 1/1000 dilution
Lane 1 : Cell media from mouse squamous cell carcinoma KLN 205 cells (treated with TPA)
Lane 2 : Cell media from mouse squamous cell carcinoma KLN 205 cells (treated with IL1-alpha)
Lane 3 : Cell media from mouse squamous cell carcinoma KLN 205 cells (treated with TNF-alpha)
Predicted band size: 178 kDa
Full-length ADAMTS12 has been detected at 178 kDa by WB. However, study looking at ADAM-TS 12 expression in COS-7 cells (Gal et al. (2001) J. Biol. Chem. 276: 17932), has detected an 83 kD COOH-terminal cleavage product.It is possible that the post-translation processing in COS-7 cells is different than that of other cells, that the epitope tag is cleaved during processing, or that the levels of the 83 kD product in other cells were below detection.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab45041 被引用在 1 文献中.
- Acar-Perk B et al. The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene. Comp Med 60:118-22 (2010). WB ; Mouse . PubMed: 20412686