重组Anti-Activin Receptor Type IIA/ACVR2A抗体[EPR7407] (ab134082)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR7407] to Activin Receptor Type IIA/ACVR2A
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-Activin Receptor Type IIA/ACVR2A抗体[EPR7407]
参阅全部 Activin Receptor Type IIA/ACVR2A 一抗 -
描述
兔单克隆抗体[EPR7407] to Activin Receptor Type IIA/ACVR2A -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF,IHC-P or IP -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide within Human Activin Receptor Type IIA/ACVR2A aa 1-100. The exact sequence is proprietary.
(Peptide available asab206674) -
阳性对照
- Human fetal liver, HepG2, HeLa, and K562 cell lysates.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
解离常数(KD)
KD = 4.37 x 10 -11 M Learn more about KD -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR7407 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab134082于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000 - 1/10000. Detects a band of approximately 80 kDa (predicted molecular weight: 58 kDa).
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说明 |
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WB
1/1000 - 1/10000. Detects a band of approximately 80 kDa (predicted molecular weight: 58 kDa). |
靶标
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功能
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. -
序列相似性
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 92 Human
- Entrez Gene: 11480 Mouse
- Entrez Gene: 29263 Rat
- Omim: 102581 Human
- SwissProt: P27037 Human
- SwissProt: P27038 Mouse
- SwissProt: P38444 Rat
- Unigene: 470174 Human
see all -
别名
- Activin A receptor type IIA antibody
- Activin receptor type 2A antibody
- Activin receptor type IIA antibody
see all
图片
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All lanes : Anti-Activin Receptor Type IIA/ACVR2A antibody [EPR7407] (ab134082) at 1/1000 dilution
Lane 1 : Human fetal liver lysate
Lane 2 : HepG2 cell lysate
Lane 3 : HeLa cell lysate
Lane 4 : K562 cell lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled Goat anti-rabbit at 1/2000 dilution
Predicted band size: 58 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab134082 被引用在 3 文献中.
- Werner CT et al. Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence. Proc Natl Acad Sci U S A 117:26460-26469 (2020). PubMed: 33020308
- Su X et al. Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development. Cell Death Dis 9:302 (2018). PubMed: 29467473
- Gancarz AM et al. Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity. Nat Neurosci : (2015). PubMed: 26030849