Anti-dimethyl Arginine抗体[21C7] (ab413)
Key features and details
- Mouse monoclonal [21C7] to dimethyl Arginine
- Suitable for: IP, WB, ChIP
- Reacts with: Species independent
- Isotype: IgM
概述
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产品名称
Anti-dimethyl Arginine抗体[21C7] -
描述
小鼠单克隆抗体[21C7] to dimethyl Arginine -
宿主
Mouse -
特异性
This antibody reacts with free and bound asymmetric NG-NG-dimethyl arginine. It is not known whether the antibody reacts with symmetric dimethyl arginine. -
经测试应用
适用于: IP, WB, ChIPmore details -
种属反应性
与反应: Species independent -
免疫原
Asymmetric NG -N G -dimethyl arginine (two methyl groups on one of the terminal nitrogen atoms of the guanidinium group)
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常规说明
This antibody will be of use in chromatin and transcription factor research to monitor methylation status. Since it is specific to dimethyl arginine it can be used in parallel with ab412 (detects monomethyl and dimethyl arginine) and ab414 (detects monomethyl arginine only) to monitor the exact modification status.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Constituents: 0.75% Glycine, 1.21% Tris, 2% Sucrose -
Concentration information loading...
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纯度
Protein A purified -
Primary antibody说明
This antibody will be of use in chromatin and transcription factor research to monitor methylation status. Since it is specific to dimethyl arginine it can be used in parallel with ab412 (detects monomethyl and dimethyl arginine) and ab414 (detects monomethyl arginine only) to monitor the exact modification status. -
克隆
单克隆 -
克隆编号
21C7 -
同种型
IgM -
轻链类型
kappa -
研究领域
相关产品
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ChIP Related Products
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Compatible Secondaries
应用
靶标
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别名
- Di methyl Arginine antibody
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (10)
ab413 被引用在 10 文献中.
- Zhou CH et al. Electroacupuncture Pretreatment Ameliorates PTSD-Like Behaviors in Rats by Enhancing Hippocampal Neurogenesis via the Keap1/Nrf2 Antioxidant Signaling Pathway. Front Cell Neurosci 13:275 (2019). PubMed: 31293390
- Albrecht LV et al. Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking. Proc Natl Acad Sci U S A 115:E5317-E5325 (2018). PubMed: 29773710
- Yaseen I et al. Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3. Nat Commun 6:8922 (2015). PubMed: 26568365
- Slade DJ et al. Chemical and biological methods to detect post-translational modifications of arginine. Biopolymers 101:133-43 (2014). PubMed: 23576281
- Hartsough EJ et al. Lysine methylation promotes VEGFR-2 activation and angiogenesis. Sci Signal 6:ra104 (2013). PubMed: 24300896
- Souki SK et al. Arginine methylation of the ICP27 RGG box regulates ICP27 export and is required for efficient herpes simplex virus 1 replication. J Virol 83:5309-20 (2009). WB . PubMed: 19321610
- Dolzhanskaya N et al. Alternative splicing modulates protein arginine methyltransferase-dependent methylation of fragile X syndrome mental retardation protein. Biochemistry 45:10385-93 (2006). PubMed: 16922515
- Komyod W et al. Are STATS arginine-methylated? J Biol Chem 280:21700-5 (2005). WB . PubMed: 15826948
- Balint BL et al. Arginine methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cells. Mol Cell Biol 25:5648-63 (2005). ChIP ; Human . PubMed: 15964820
- Mowen KA et al. Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell 104:731-41 (2001). IP . PubMed: 11257227