Mitomycin C (MMC),Anticancer and antibiotic agent (ab120797)
Key features and details
- Anticancer and antibiotic agent
- CAS Number: 50-07-7
- Purity: > 99%
Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Streptomyces sp.
概述
-
产品名称
Mitomycin C (MMC),Anticancer and antibiotic agent -
描述
Anticancer and antibiotic agent -
别名
- MMC
-
纯度
> 99% -
CAS编号
50-07-7 -
化学结构
性能
-
化学名称
(1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
-
分子量
334.33 -
分子式
C15H18N4O5 -
PubChem识别号
5746 -
存放说明
Store at +4°C. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM
-
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N -
来源
Streptomyces sp.
-
研究领域
相关产品
-
Alternative Versions
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120797于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Functional Studies |
Use at an assay dependent concentration.
|
说明 |
---|
Functional Studies
Use at an assay dependent concentration. |
图片
-
2D chemical structure image of ab120797, Mitomycin C (MMC), Anticancer and antibiotic agent
-
Functional assays: Caspase 8 (active) FITC Staining Kit (ab65614)
Active caspase 8 in control Jurkat cells (10e6/mL) or cells treated for five hours with 10 ug/mL Cyclohexamide (CHX) (ab120093) or four hours with 25 ug/mL Mitomycin C (MitoC) (ab120797). Background signal subtracted, duplicates; +/- SD.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (7)
ab120797 被引用在 7 文献中.
- Sinha S et al. Dynamically Crosslinked Poly(ethylene-glycol) Hydrogels Reveal a Critical Role of Viscoelasticity in Modulating Glioblastoma Fates and Drug Responses in 3D. Adv Healthc Mater 12:e2202147 (2023). PubMed: 36239185
- Azimi Lamouty M et al. Fabrication of Cell-Laden AME-Loaded Collagen-Based Hydrogel Promotes Fibroblast Proliferation and Wound Healing In Vitro. Cell J 25:255-263 (2023). PubMed: 37210646
- Huang CJ et al. Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process. Mol Med Rep 28:N/A (2023). PubMed: 37387413
- Chiou AE et al. Fluorescent Silica Nanoparticles to Label Metastatic Tumor Cells in Mineralized Bone Microenvironments. Small 17:e2001432 (2021). PubMed: 32462807
- Ruggiano A et al. The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability. Cell Rep 37:110080 (2021). PubMed: 34879279
- Li J et al. A multi-targeted tyrosine kinase inhibitor lenvatinib for the treatment of mice with advanced glioblastoma. Mol Med Rep 16:7105-7111 (2017). PubMed: 28901423
- Massee M et al. Type I and II Diabetic Adipose-Derived Stem Cells Respond In Vitro to Dehydrated Human Amnion/Chorion Membrane Allograft Treatment by Increasing Proliferation, Migration, and Altering Cytokine Secretion. Adv Wound Care (New Rochelle) 5:43-54 (2016). PubMed: 26862462