Anti-Von Willebrand Factor抗体(ab11713)
Key features and details
- Sheep polyclonal to Von Willebrand Factor
- Suitable for: Immunodiffusion, ELISA, ICC/IF, IHC-Fr, Flow Cyt
- Reacts with: Mouse, Human, Pig
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Von Willebrand Factor抗体
参阅全部 Von Willebrand Factor 一抗 -
描述
羊多克隆抗体to Von Willebrand Factor -
宿主
Sheep -
经测试应用
适用于: Immunodiffusion, ELISA, ICC/IF, IHC-Fr, Flow Cytmore details
不适用于: IHC-P -
种属反应性
与反应: Mouse, Human, Pig -
免疫原
Full length native protein (purified) corresponding to Human Von Willebrand Factor. Purified human von Willebrand factor prepared from citrated human plasma
Database link: P04275 -
常规说明
This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.09% Sodium azide
Constituents: Glycine buffered saline, 0.1% EACA, 0.01% Benzamidine, 0.0292% EDTA -
Concentration information loading...
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纯度
Ion Exchange Chromatography -
纯化说明
Purified IgG was prepared from serum by ion exchange chromatography. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab11713于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Immunodiffusion |
Use at an assay dependent concentration.
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|
ELISA |
Use at an assay dependent concentration.
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|
ICC/IF | (2) |
Use at an assay dependent concentration.
|
IHC-Fr | (6) |
Use at an assay dependent concentration.
|
Flow Cyt |
Use at an assay dependent concentration.
ab37385 - Sheep polyclonal IgG, is suitable for use as an isotype control with this antibody. |
说明 |
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Immunodiffusion
Use at an assay dependent concentration. |
ELISA
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. ab37385 - Sheep polyclonal IgG, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. -
组织特异性
Plasma. -
疾病相关
Defects in VWF are the cause of von Willebrand disease (VWD) [MIM:277480]. VWD defines a group of hemorrhagic disorders in which the von Willebrand factor is either quantitatively or qualitatively abnormal resulting in altered platelet function. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII and impaired platelet adhesion. Type I von Willebrand disease is the most common form and is characterized by partial quantitative plasmatic deficiency of an otherwise structurally and functionally normal Willebrand factor; type II is associated with a qualitative deficiency and functional anomalies of the Willebrand factor; type III is the most severe form and is characterized by total or near-total absence of Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. -
序列相似性
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 4 TIL (trypsin inhibitory-like) domains.
Contains 3 VWFA domains.
Contains 3 VWFC domains.
Contains 4 VWFD domains. -
结构域
The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules. -
翻译后修饰
All cysteine residues are involved in intrachain or interchain disulfide bonds.
N- and O-glycosylated. -
细胞定位
Secreted. Secreted > extracellular space > extracellular matrix. Localized to storage granules. - Information by UniProt
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数据库链接
- Entrez Gene: 7450 Human
- Entrez Gene: 22371 Mouse
- Omim: 613160 Human
- SwissProt: P04275 Human
- SwissProt: Q8CIZ8 Mouse
- Unigene: 440848 Human
- Unigene: 22339 Mouse
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别名
- Coagulation factor VIII antibody
- Coagulation factor VIII VWF antibody
- F8VWF antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (105)
ab11713 被引用在 105 文献中.
- Galley JC et al. Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT1 receptor-forkhead box subclass O transcription factor signalling axis. Br J Pharmacol 179:2490-2504 (2022). PubMed: 33963547
- Li B et al. RNA N6-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice. Elife 11:N/A (2022). PubMed: 35001873
- Huisman C et al. Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing. Mol Metab 58:101441 (2022). PubMed: 35031523
- Desilles JP et al. Impact of COVID-19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID-19 patients with acute ischemic stroke. J Thromb Haemost 20:919-928 (2022). PubMed: 35032088
- Dosunmu-Ogunbi A et al. Endothelial superoxide dismutase 2 is decreased in sickle cell disease and regulates fibronectin processing. Function (Oxf) 3:zqac005 (2022). PubMed: 35274104