存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.1% Sodium azide
Constituents: 0.0268% PBS, 1% BSA
Concentration information loading...
纯度Immunogen affinity purified
Our Abpromise guarantee covers the use of ab82173 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
|WB||Use at an assay dependent concentration.|
功能Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
组织特异性Expressed in ureter.
疾病相关Defects in UPK3A are a cause of renal adysplasia (RADYS) [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.
序列相似性Belongs to the uroplakin-3 family.
细胞定位Endoplasmic reticulum membrane. Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
- Information by UniProt
- MGC119178 antibody
- OTTHUMP00000028951 antibody
- UP III antibody
This product has been referenced in:
- Hou T et al. Aberrant differentiation of urothelial cells in patients with ureteropelvic junction obstruction. Int J Clin Exp Pathol 7:5837-45 (2014). IF ; Human . Read more (PubMed: 25337225) »
- Hicks AN et al. Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2): Consequences for mouse bladder development and function. Neurourol Urodyn : (2013). Read more (PubMed: 23371862) »