The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Predicted molecular weight: 119 kDa.
1/400. Acetone fixed.
Use at an assay dependent dilution.
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
Belongs to the Toll-like receptor family. Contains 23 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 TIR domain.
Wang Y et al. Increased infiltration of CD11 c+/CD123+ dendritic cell subsets and upregulation of TLR/IFN-a signaling participate in pathogenesis of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol125:459-467.e2 (2018).
Read more (PubMed: 29429903) »
Jiang C et al. The Expression of Toll-like receptors in eutopic and ectopic endometrium and its implication in the inflammatory pathogenesis of adenomyosis. Sci Rep7:7365 (2017).
Read more (PubMed: 28779087) »