重组人ENSA蛋白(ab92932)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% SDS-PAGE
- Suitable for: SDS-PAGE
描述
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产品名称
重组人ENSA蛋白 -
纯度
> 90 % SDS-PAGE.
ab92932 is purified using conventional chromatography techniques. -
表达系统
Escherichia coli -
蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human -
序列
MGSSHHHHHH SSGLVPRGSH MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV E
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab92932 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
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形式
Liquid -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 8.00
Constituents: 0.0154% DTT, 0.316% Tris HCl, 10% Glycerol
常规信息
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别名
- Alpha endosulfine
- Alpha-endosulfine
- ARPP 19e
see all -
功能
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. -
组织特异性
Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. -
序列相似性
Belongs to the endosulfine family. -
翻译后修饰
Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA. -
细胞定位
Cytoplasm. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab92932 被引用在 2 文献中.
- Watamura N et al. Somatostatin-evoked Aß catabolism in the brain: Mechanistic involvement of a-endosulfine-KATP channel pathway. Mol Psychiatry 27:1816-1828 (2022). PubMed: 34737456
- Marzec KA et al. SILAC kinase screen identifies potential MASTL substrates. Sci Rep 12:10568 (2022). PubMed: 35732702