FITC荧光Anti-Myeloperoxidase抗体[2C7] (ab11729)
Key features and details
- FITC Mouse monoclonal [2C7] to Myeloperoxidase
- Suitable for: Flow Cyt (Intra)
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
Related conjugates and formulations
概述
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产品名称
FITC荧光Anti-Myeloperoxidase抗体[2C7]
参阅全部 Myeloperoxidase 一抗 -
描述
FITC荧光小鼠单克隆抗体[2C7] to Myeloperoxidase -
宿主
Mouse -
偶联物
FITC. Ex: 493nm, Em: 528nm -
经测试应用
适用于: Flow Cyt (Intra)more details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein corresponding to Human Myeloperoxidase.
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阳性对照
- human peripheral blood granulocytes: Flow Cyt (Intra).
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常规说明
This product should be stored undiluted. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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纯度
Protein G purified -
纯化说明
Purified IgG prepared by affinity chromatography. -
克隆
单克隆 -
克隆编号
2C7 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG1 -
研究领域
相关产品
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Alternative Versions
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Assay kits
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab11729于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt (Intra) |
1/1 - 1/10.
Use 10µl of the suggested working dilution to label 106 cells in 100µl. This antibody may be used for the flow cytometric detection of myeloid cells following membrane permeablisation. ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
说明 |
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Flow Cyt (Intra)
1/1 - 1/10. Use 10µl of the suggested working dilution to label 106 cells in 100µl. This antibody may be used for the flow cytometric detection of myeloid cells following membrane permeablisation. ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. -
疾病相关
Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis. -
序列相似性
Belongs to the peroxidase family. XPO subfamily. -
细胞定位
Lysosome. - Information by UniProt
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数据库链接
- Entrez Gene: 4353 Human
- Omim: 606989 Human
- SwissProt: P05164 Human
- Unigene: 458272 Human
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别名
- 84 kDa myeloperoxidase antibody
- 89 kDa myeloperoxidase antibody
- EC 1.11.1.7 antibody
see all
图片
实验方案
数据表及文件
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Datasheet download
文献 (13)
ab11729 被引用在 13 文献中.
- Kuźmicka W et al. Influence of iron- and zinc-chelating agents on neutrophil extracellular trap formation. Cent Eur J Immunol 46:135-139 (2021). PubMed: 34764782
- Manda-Handzlik A et al. Nitric oxide and peroxynitrite trigger and enhance release of neutrophil extracellular traps. Cell Mol Life Sci 77:3059-3075 (2020). PubMed: 31650185
- Mroczek A et al. Overexpression of ATG5 Gene Makes Granulocyte-Like HL-60 Susceptible to Release Reactive Oxygen Species. Int J Mol Sci 21:N/A (2020). PubMed: 32707918
- Kuzmicka W et al. Zinc Supplementation Modulates NETs Release and Neutrophils' Degranulation. Nutrients 13:N/A (2020). PubMed: 33375275
- Schneck E et al. Flow Cytometry-Based Quantification of Neutrophil Extracellular Traps Shows an Association with Hypercoagulation in Septic Shock and Hypocoagulation in Postsurgical Systemic Inflammation-A Proof-of-Concept Study. J Clin Med 9:N/A (2020). PubMed: 31936385