Anti-Hsp105/HSP110抗体(ab24503)
Key features and details
- Rabbit polyclonal to Hsp105/HSP110
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Hsp105/HSP110抗体
参阅全部 Hsp105/HSP110 一抗 -
描述
兔多克隆抗体to Hsp105/HSP110 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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常规说明
This product is manufactured by BioVision, an Abcam company and was previously called 3390 Hsp105 Antibody. 3390-100 is the same size as the 100 µg size of ab24503.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab24503于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 105 kDa (predicted molecular weight: 97 kDa).
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说明 |
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WB
Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 105 kDa (predicted molecular weight: 97 kDa). |
靶标
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功能
Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. -
组织特异性
Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. -
序列相似性
Belongs to the heat shock protein 70 family. -
翻译后修饰
Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 10808 Human
- Omim: 610703 Human
- SwissProt: Q92598 Human
- Unigene: 36927 Human
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别名
- Antigen NY CO 25 antibody
- Antigen NY-CO-25 antibody
- DKFZp686M05240 antibody
see all
图片
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Anti-Hsp105/HSP110 antibody (ab24503) (1 - 4 ug/ml) + HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7898)
Predicted band size: 97 kDa
Observed band size: 105 kDa why is the actual band size different from the predicted?
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab24503 被引用在 1 文献中.
- Shorter J The Mammalian disaggregase machinery: hsp110 synergizes with hsp70 and hsp40 to catalyze protein disaggregation and reactivation in a cell-free system. PLoS One 6:e26319 (2011). IP ; Human, Rat . PubMed: 22022600