Beta Secretase底物(ab101160)
概述
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产品名称
Beta Secretase底物
参阅全部 Beta secretase 试剂盒 -
产品概述
This is a component of Beta Secretase Activity Assay (Fluorometric) (ab65357).
性能
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存放说明
Store at -20°C. Please refer to protocols. -
组件 200 µl β-Secretase Substrate 1 x 200µl -
研究领域
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相关性
Beta secretase is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. Beta APP cleavage by beta-secretase results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. -
细胞定位
Membrane; Single-pass type I membrane protein. -
别名
- APP beta secretase
- ASP 2
- ASP2
see all
相关产品
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Corresponding kit
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab101160 尚未被引用在任何文献中。