Anti-Aromatase抗体(ab18995)
Key features and details
- Rabbit polyclonal to Aromatase
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Aromatase抗体
参阅全部 Aromatase 一抗 -
描述
兔多克隆抗体to Aromatase -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Chicken, Cow, Pig -
免疫原
Synthetic peptide surrounding amino acid 385 of human Aromatase (Peptide available as ab51924.)
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常规说明
This product is manufactured by BioVision, an Abcam company and was previously called 3599 Aromatase Antibody.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab18995于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (3) |
Use a concentration of 0.5 - 4 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 58 kDa). An additional 35 kDa band can also be detected in Jurkat cells (we are unsure of the identity).
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说明 |
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WB
Use a concentration of 0.5 - 4 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 58 kDa). An additional 35 kDa band can also be detected in Jurkat cells (we are unsure of the identity). |
靶标
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功能
Catalyzes the formation of aromatic C18 estrogens from C19 androgens. -
组织特异性
Brain, placenta and gonads. -
疾病相关
Defects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity.
Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:107910]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries. -
序列相似性
Belongs to the cytochrome P450 family. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 414854 Chicken
- Entrez Gene: 1588 Human
- Omim: 107910 Human
- SwissProt: P19098 Chicken
- SwissProt: P11511 Human
- Unigene: 260074 Human
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别名
- ARO antibody
- ARO1 antibody
- Aromatase antibody
see all
图片
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Anti-Aromatase antibody (ab18995) at 1 µg/ml + Human brain normal tissue lysate - membrane extract (ab29456) at 10 µg
Secondary
Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
Developed using the ECL technique.
Performed under reducing conditions.
Predicted band size: 58 kDa
Observed band size: 58 kDa
Additional bands at: 34 kDa. We are unsure as to the identity of these extra bands.
Exposure time: 1 minute
数据表及文件
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SDS download
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Datasheet download
文献 (67)
ab18995 被引用在 67 文献中.
- Krawczyk K et al. Persistent organic pollutants affect steroidogenic and apoptotic activities in granulosa cells and reactive oxygen species concentrations in oocytes in the mouse. Reprod Fertil Dev 35:294-305 (2023). PubMed: 36403477
- Zhang Y et al. Zika Virus Infection in the Ovary Induces a Continuously Elevated Progesterone Level and Compromises Conception in Interferon Alpha/Beta Receptor-Deficient Mice. J Virol 96:e0118921 (2022). PubMed: 34730391
- Walker RR et al. Glyceollins Trigger Anti-Proliferative Effects in Hormone-Dependent Aromatase-Inhibitor-Resistant Breast Cancer Cells through the Induction of Apoptosis. Int J Mol Sci 23:N/A (2022). PubMed: 35270029
- Fadeyibi O et al. The Role of Lipid Rafts and Membrane Androgen Receptors in Androgen's Neurotoxic Effects. J Endocr Soc 6:bvac030 (2022). PubMed: 35308305
- Chen T et al. Effect of e-cigarette refill liquid on follicular development and estrogen secretion in rats. Tob Induc Dis 20:36 (2022). PubMed: 35529323