Anti-Aquaporin 4抗体(ab125049)
Key features and details
- Rabbit polyclonal to Aquaporin 4
- Suitable for: ICC/IF, WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-Aquaporin 4抗体
参阅全部 Aquaporin 4 一抗 -
描述
兔多克隆抗体to Aquaporin 4 -
宿主
Rabbit -
经测试应用
适用于: ICC/IF, WBmore details -
种属反应性
与反应: Rat -
免疫原
Synthetic peptide:
N-CTKGSYMEVEDNRSQVETED
, corresponding to C terminal amino acids 273-291 of Rat Aquaporin 4 (NP_036957.1). -
阳性对照
- Rat kidney lysate; Rat kidney tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20ºC. -
存储溶液
Preservative: 0.09% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab125049于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ICC/IF |
1/200 - 1/400.
|
|
WB |
1/1000 - 1/4000. Predicted molecular weight: 35 kDa.
|
说明 |
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ICC/IF
1/200 - 1/400. |
WB
1/1000 - 1/4000. Predicted molecular weight: 35 kDa. |
靶标
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功能
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. -
组织特异性
Brain - muscle >> heart, kidney, lung, and trachea. -
序列相似性
Belongs to the MIP/aquaporin (TC 1.A.8) family. -
结构域
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). -
翻译后修饰
Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamats increases conductance by 40%. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 25293 Rat
- SwissProt: P47863 Rat
- Unigene: 90091 Rat
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别名
- AQP 4 antibody
- AQP-4 antibody
- AQP4 antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab125049 被引用在 3 文献中.
- Sanches E et al. Dose-Dependent Neuroprotective Effects of Bovine Lactoferrin Following Neonatal Hypoxia-Ischemia in the Immature Rat Brain. Nutrients 13:N/A (2021). PubMed: 34836132
- Deng S et al. Relationship Between Pregnancy and Acute Disseminated Encephalomyelitis: A Single-Case Study. Front Immunol 11:609476 (2020). PubMed: 33597947
- Somers E et al. Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy. Ann Neurol 79:217-30 (2016). PubMed: 26506088