Recombinant protein fragment contain a sequence corresponding to a region within amino acids 249-460 of Human ZWILCH.
NT2D1, IMR32, U-87 MG, MCF7
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7
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Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 54 kDa.
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).
Belongs to the ZWILCH family.
Chromosome, centromere, kinetochore.
Information by UniProt
homolog of Drosophila Zwilch antibody
Anti-ZWILCH antibody (ab101403)参考文献
has not yet been referenced specifically in any publications.
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