Anti-ZRANB1抗体(ab82132)
Key features and details
- Goat polyclonal to ZRANB1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ZRANB1抗体
参阅全部 ZRANB1 一抗 -
描述
山羊多克隆抗体to ZRANB1 -
宿主
Goat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Cow -
免疫原
Synthetic peptide:
KWLDRYRQIRPCTS
, corresponding to C terminal amino acids 682-695 of Human ZRANB1 -
阳性对照
- Human Cerebellum Lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, Tris buffered saline -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab82132于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 81 kDa.
1 hour primary incubation is recommended for this product. |
说明 |
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WB
Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 81 kDa. 1 hour primary incubation is recommended for this product. |
靶标
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功能
Positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. Acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription. May also modulate TNF-alpha signaling. -
组织特异性
Widely expressed. -
序列相似性
Belongs to the peptidase C64 family.
Contains 1 OTU domain.
Contains 3 RanBP2-type zinc fingers. -
结构域
The OTU domain mediates the deubiquitinating activity.
The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin. -
细胞定位
Cytoplasm. Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 54764 Human
- Entrez Gene: 360216 Mouse
- Omim: 611749 Human
- SwissProt: Q9UGI0 Human
- SwissProt: Q7M760 Mouse
- Unigene: 595158 Human
- Unigene: 389984 Mouse
- Unigene: 397069 Mouse
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别名
- DKFZp762P2216 antibody
- hTrabid antibody
- Trabid antibody
see all
图片
数据表及文件
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Datasheet download
文献 (1)
ab82132 被引用在 1 文献中.
- Li Q et al. Deubiquitinase ZRANB1 drives hepatocellular carcinoma progression through SP1-LOXL2 axis. Am J Cancer Res 11:4807-4825 (2021). PubMed: 34765294