概述

  • 产品名称Anti-ZP2抗体
    参阅全部 ZP2 一抗
  • 描述
    小鼠单克隆抗体to ZP2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 400-510 of Human ZP2 with a Proprietary tag (NP_003451).

  • 阳性对照
    • Recombinant fragment of ZP2 protein

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液pH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab118073 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 82 kDa. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

靶标

  • 功能The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
  • 组织特异性Oocytes.
  • 序列相似性Belongs to the ZP domain family. ZPA subfamily.
    Contains 1 ZP domain.
  • 发展阶段Expressed during the 2-week growth phase of oogenesis, prior to ovulation.
  • 结构域The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
  • 翻译后修饰Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
    Proteolytically cleaved in the N-terminal part after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy.
    O-glycosylated; contains sulfate-substituted glycans.
  • 细胞定位Secreted > extracellular space > extracellular matrix and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • OTTHUMP00000115849 antibody
    • Processed zona pellucida sperm-binding protein 2 antibody
    • Zona pellucida glycoprotein 2 antibody
    • zona pellucida glycoprotein ZP2 antibody
    • Zona pellucida protein A antibody
    • Zp-2 antibody
    • ZP2 antibody
    • ZP2_HUMAN antibody
    • ZPA antibody
    see all

Anti-ZP2 antibody 图像

  • Anti-ZP2 antibody (ab118073) at 5 µg/ml + Recombinant fragment of ZP2 with Proprietary tag at 0.2 µg

    Predicted band size : 82 kDa

Anti-ZP2 antibody (ab118073)参考文献

ab118073 has not yet been referenced specifically in any publications.

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