概述

  • 产品名称
  • 描述
    兔多克隆抗体to ZNRF2
  • 经测试应用
    适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 100-150 of Human ZNRF2 (NP_667339.1).

  • 阳性对照
    • Whole cell lysate from HeLa cells.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate
    Note: pH: 7 to 8
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab114098 was affinity purified using an epitope specific to ZNRF2 immobilized on solid support.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab114098 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 10 µg/mg of lysate.
  • 应用说明
    Is unsuitable for WB.
  • 靶标

    • 功能
      May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
    • 组织特异性
      Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.
    • 通路
      Protein modification; protein ubiquitination.
    • 序列相似性
      Contains 1 RING-type zinc finger.
    • 结构域
      The RING-type zinc finger domain is required for E3 ligase activity.
    • 翻译后修饰
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位
      Endosome membrane. Lysosome membrane. Cell junction > synapse > presynaptic cell membrane. Present in presynaptic plasma membranes in neurons.
    • Information by UniProt
    • 数据库链接
    • 别名
      • E3 ubiquitin-protein ligase ZNRF2 antibody
      • Protein Ells2 antibody
      • RING finger protein 202 antibody
      • RNF202 antibody
      • Zinc/RING finger protein 2 antibody
      • Znrf2 antibody
      • ZNRF2_HUMAN antibody
      see all

    Anti-ZNRF2 antibody 图像

    • Rabbit anti-ZNRF2 antibody, at 1 µg/ml, staining ZNRF2 in HeLa whole cell lysate immunoprecipitated using ab114098 at 10 µg/mg lysate (1 mg for IP; 20% of IP loaded/lane). Detection: Chemiluminescence with an exposure time of 30 seconds.

    Anti-ZNRF2 antibody (ab114098)参考文献

    ab114098 has not yet been referenced specifically in any publications.

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