概述

  • 产品名称
    ZM 449829
  • 描述
    Potent,selective,ATP-competitive JAK3抑制剂. Potent transglutaminase抑制剂.
  • 生物学描述
    Potent, selective, ATP-competitive JAK3 inhibitor (pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively). Potent transglutaminase inhibitor (IC50 = 10 nM). Inhibits STAT5 phosphorylation and T cell proliferation.
  • 纯度
    > 98%

性能

  • 化学名称
    1-(2-Naphthalenyl)-2-propen-1-one
  • 分子量
    182.22
  • 化学结构
    Chemical Structure
  • 分子式
    C13H10O
  • CAS编号
    4452-06-6
  • PubChem识别号
    3799
  • 存放说明
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述
    Soluble in DMSO and in ethanol
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C=CC(=O)C1=CC2=CC=CC=C2C=C1
  • 来源

    Synthetic

  • 研究领域

文献

This product has been referenced in:
  • Lai TS  et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol 15:969-78 (2008). Read more (PubMed: 18804034) »
  • Gross ER  et al. The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Am J Physiol Heart Circ Physiol 291:H827-34 (2006). Read more (PubMed: 16517948) »

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