Anti-ZIP Kinase (phospho T265)抗体(ab63395)


  • 产品名称
    Anti-ZIP Kinase (phospho T265)抗体
    参阅全部 ZIP Kinase 一抗
  • 描述
    兔多克隆抗体to ZIP Kinase (phospho T265)
  • 特异性
    This antibody detects endogenous levels of ZIP kinase only when phosphorylated at threonine 265.
  • 经测试应用
    适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide corresponding to Human ZIP Kinase aa 241-290 (phospho T265).
    Database link: O43293

  • 阳性对照
    • A549 cells and extracts from HuvEc cells



Our Abpromise guarantee covers the use of ab63395 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 53 kDa (predicted molecular weight: 53 kDa).
ICC/IF 1/100 - 1/500.


  • 功能
    Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.
  • 序列相似性
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰
    Ubiquitinated. Ubiquitination mediated by the UBE2D3 E3 ligase does not lead to proteasomal degradation, but influences promyelocytic leukemia protein nuclear bodies (PML-NBs) formation in the nucleus.
    Autophosphorylated. Phosphorylated by ROCK1.
  • 细胞定位
    Nucleus. Cytoplasm. Nucleus > PML body. Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (By similarity). Localizes to promyelocytic leukemia protein nuclear bodies (PML-NBs). Associates to centromeres from prophase to anaphase.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DAP kinase 3 antibody
    • DAP like kinase antibody
    • DAP-like kinase antibody
    • Dapk 3 antibody
    • DAPK3 antibody
    • DAPK3_HUMAN antibody
    • Death associated kinase 3 antibody
    • Death associated protein kinase 3 antibody
    • Death-associated protein kinase 3 antibody
    • Dlk antibody
    • EC antibody
    • FLJ36473 antibody
    • MYPT1 kinase antibody
    • ZIP antibody
    • ZIP kinase antibody
    • ZIP kinase isoform antibody
    • ZIP-kinase antibody
    • ZIPK antibody
    • zipper-interacting protein kinase antibody
    see all

Anti-ZIP Kinase (phospho T265) antibody 图像

  • Immunofluorescence analysis of A549 cells, using ab63395 at a 1:500.
    Left image untreated.
    Right image treated with phospho peptide.
  • All lanes : Anti-ZIP Kinase (phospho T265) antibody (ab63395) at 1/500 dilution

    Lane 1 : Extracts of HuvEc cells
    Lane 2 : Extracts of HuvEc cells plus phospho petide

    Predicted band size : 53 kDa
    Observed band size : 53 kDa

Anti-ZIP Kinase (phospho T265) antibody (ab63395)参考文献

ab63395 has not yet been referenced specifically in any publications.

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